Polypeptides copolymers

Siloxane-polybutadiene copolymers 45 Siloxane-polyethylene copolymers 45 Siloxane-polypeptide copolymers 51 Siloxane-silarylenesiloxane copolymers 27, 41... 

Kim KT, Winnik MA, Manners I. Synthesis and self-assembly of dendritic-helical block polypeptide copolymers. Soft Matter 2006 2 957-965. 

Figure 4. Influence of urea and pH on the solubilities of synthetic polypeptide copolymers of glutamine and glutamic acid (17)...

N 041 "Conformational Energy and Unperturbed Chain Dimensions of Polypeptide Copolymers ... 

Calculations of end-to-end distances of random coil conformations have also been carried out for polypeptide copolymers (Miller et al., 1967). The values of (rzyQlnplz were found to vary markedly with composition and amino acid sequence in the copolymers. For example, the introduction of glycine residues randomly into poly-L-alanine led to a monotonic decrease 6 ... 

Farthing. Nature 163, 834-5 (1949). Crystal structure polypeptide copolymers. 

Examination of the random coil configuration of polypeptide copolymers has also led to very interesting results. The study of copoly-... 

Abstract The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence of secondary structure effects. Structure elements like a-helix or / -sheet can induce a deviation from the classical phase behaviour and promote the formation of vesicles or hierarchical superstructures with ordering in the length-scale of microns. Polypeptide copolymers are therefore considered as models to study self-assembly processes in biological systems. In addition, they offer a great potential for a production of novel advanced materials and colloids. 

The phase behaviour of biomimetic polypeptide-based copolymers in solution was described and discussed with respect to the occurrence of secondary structure effects. Evidently, incorporation of crystallisable polypeptide segments inside the core of an aggregate has impact on the curvature of the corecorona interface and promotes the formation of fibrils or vesicles or other flat superstructures. Spherical micelles are usually not observed. Copolymers with soluble polypeptide segments, on the other hand, seem to behave like conventional block copolymers. A pH-induced change of the conformation of coronal polypeptide chains only affects the size of aggregates but not their shape. The lyotropic phases of polypeptide copolymers indicate the existence of hierarchical superstructures with ordering in the length-scale of microns. 

The application potential of polypeptide copolymers has also not been exhausted. Most studies deal with ordinary micelles for the controlled delivery of drugs or genes. Not much attention has, for whatever reason, been paid to other colloidal systems like for instance emulsions, polymer latexes, and inorganic-organic biohybrid nanoparticles. 

Cylindrical Micelles Self-Assembled from Polypeptide Copolymers. 181... 

Vesicles Self-Assembled firm Polypeptide Copolymers. 186... 

The ordered structures assembled from polypeptide homopolymers and copolymers in both bulk and solution have attracted a great deal of attention over the past few decades and could continue to be an active theme in the future [30-38]. In solution, both the a-helix and p-sheet conformations of polypeptides facilitate the formation of ordered structures in liquid crystals (LCs), gels, and micelles during the assembly process. Usually, LC structures are assembled from polypeptide homopolymers in concentrated solutions [39-41]. In solutions with moderate concentrations, gels are usually formed by both polypeptide homopolymers and copolymers [42-44]. In dilute solutions, polypeptide copolymers are able to self-assemble into diverse micelle structures with a solvophilic shell, while the solvophobic polypeptide chains are packed in an ordered manner in the micelle core [45 7]. 

Polypeptide copolymers can assemble into gels in organic solvent through ordered packing of polypeptide blocks with conformations of both a-helix and p-sheet [44, 48, 53, 54, 95-100]. For copolymers with a-helix polypeptides, fhe side-by-side packing of the polypeptide rods in a smectic fashion has been commonly observed. For the copolymers with p-sheet polypeptides, the strong intermolecular... 

Organic Gels from Polypeptide Copolymer with a-Helix Conformation... 

Kim KT, Park C, Kim C, Winnik MA, Manners I (2006) Self-assembly of dendron-helical polypeptide copolymers organogels and lyotropic liquid crystals. Chem Commnn 1372-1374... 

Fig. 6 Preparation of core-shell drug delivery micelles, (a) Unfolding of globular protein to prepare protein-derived polypeptide copolymers with exposed internal ftmctitmal groups, (b) Preparation of onion-type core-shell drug delivery micelles from albumin-derived polypeptide copolymers and the two step release mechanism (adopted and modified from Wu et al. [44])...

Wu Y, Pramanik G, Eisele K, Weil T (2012) Convenient approach to polypeptide copolymers derived from native proteins. Biomacromolecules 13 1890-1898. doi 10.1021/bm300418r... 

Rao, J., Zhang, Y., Zhang, J., Lin, S. (2008). Facile preparation of well-defined AB2 Y-shaped Miktoarm star polypeptide copolymer via the combination of ring-opening polymerization and chck chemistry. Biomacromolecules, 9, 2586-2593. 

---