Chck chemistry

O Reilly RK, Joralemon MJ, Wooley KL, Hawker CJ. Functionalization of micelles and shell cross-linked nanoparticles using chck chemistry. Chem Mater 2005 17 5976-5988. 

Kolb, H.C., Finn, M.G, Sharpless, K.B. Chck chemistry diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 2001, 40, 2004—2021. 

Brennan JL, Hatzakis NS, Tshikhudo TR, Dirvianskyte N, Razumas V, Patkar S, Vind J, Svendsen A, Nolle RJM., Rowan AE, Brust M. Bionanoconjugation via chck chemistry The creation of functional hybrids of hpases and gold nanoparticles. Bioconj. Chem. 2006 17 1373-1375. 

Lewis, W. G., Green, L. G., Grynszpan, E, Radic, Z., Carlier, P. R., Taylor, P, Finn, M. G., Sharpless, K. B. Chck chemistry in situ acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of btrilding blocks. Angew. Chem. Int. Ed. 2002, 41, 1053-1057. 

The first contribution in the development of sugar arrays based on cHck chemistry was reported by Fazio et al. [79] who described the use of Cu(l)-catalyzed triazole formation for the synthesis and in-situ non-covalent attachment of saccharides to the surface of microtiter plates through Hpid tethers (Scheme 23). The alkyne cHckable counterpart was prepared from a Ci4 aliphatic chain that was conjugated with a series of 2-azidoethyl -D-glycosides on miaomolar scale by using an experimental protocol that avoided purification procedures, hi an effort to extend this approach to the covalent attachment of saccharides to the microtiter plate surface, Bryan et al. [80] reported a strategy based on bifunctional Hnkers (115 and 116). 

Gold nanoparticles deposited onto a carbon electrode and modified with sialic acid derivatives by chck chemistry were used for electrochemical sensing of interactions between siahc acid and Alzheimer s amyloid-beta (AP) peptides. The attachment of Ap peptides to the siahc acid layer was confirmed by electrochemistry and AFM imaging. The peak oxidation-current response of Tyr residue of AP was utilized as the analytical signal. 

M. Urien, H. Erothu, E. Cloutet, R. C. Hiorns, L. Vignau, H. Cramail, Poly(3-Hexylthiophene) Based Block Copolymers Prepared by Chck Chemistry. Macromolecules 2008,41,7033-7040. 

This chck chemistry-based approach to ABPP even works in live animals to determine specific protein expression levels. As an example, PS-N3 (366) was injected into living mice to investigate ECH-1 expression in the heart tissue. One hour after injection, the mice were sacrificed, and ECH-1 was successfully detected by staining the crude heart-homogenate via Cu(l)-catalyzed bioconjugation using a Rh-alkyne tag 367 (Scheme 74B) [233]. 

By cHck chemistry PS, PtBA, or PwBA polymers with Br terminus were first... 

The DA chck reaction, a [4 + 2] cycloaddition system based on the coupHng of a diene and a dienophile, represents an alternative strategy in chck chemistry [26-28]. This reaction has been applied successfully to the preparation of block copolymers with PEO and PSt or PMMA segments, prepared using AROP and ATRP or nitroxide-mediated radical polymerization (NMRP) [26-28]. Thus, PEO-b-PSt and PEO-h-PMMA block copolymers were synthesized via DA chck reaction of maleimide- and anthracene end-functionahzed polymers. The overall strategy is represented in Scheme 11.3, as the preparation of PEO-h-PSt... 

To achieve similar structures, Monteiro etal. have resorted to a combination of ATRP and chck chemistry [71] whilst, in a variant approach, Tunca... 

This chapter will serve to highlight recent advances in polymer science that have been aided by the use of click chemistry. The copper(l)-catalyzed azide-alkyne cycloaddition (CuAAC) and thiol-ene reactions will be discussed first, after which the utilization of these chemical transformations in the construction and fimction-ahzation of a multitude of different polymeric materials will be outlined. Particular attention will be focused on the preparation of highly complex polymer architectures, such as dendrimers and star polymers, which exempHfy the essential role that chck chemistry has assumed in the polymer science community. 

CHE2 Chen, J., Liu, M., Gong, H., Huang, Y., and Chen, C., Synthesis and self-assembly of thermoresponsive PEG-Z>-PNIPAM-Z>-PCL ABC triblock copolymer through the combination of atom transfer radical polymerization, ring-opening polymerization, and chck chemistry, J. Phys. Chem. B, 115, 14947, 2011. 

When cyclodextrins meet cHck chemistry 12EJO4087. 

Metal-catalyzed chck chemistry for molecular imaging probes 13 COC594. 

Chck chemistry for drug development and diverse chemical—biology applications 13CRV4905. 

Peptide conjugation via copper(I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) chck chemistry 13MOL13148. 

Chemical architecture and appUcations of nucleic acid derivatives containing 1,2,3-triazole functionahties synthesized via cHck chemistry 12MOL12665. 

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