Modification of Polypeptides with Fatty Acids and Amphiphilic Block Copolymers

Chemical Modification of Polypeptides with Fatty Acids and Amphiphilic Block Copolymers 

Tremendous efforts in the last several decades have resulted in numerous invendons of CNS drug delivery systems. Many of these innovadve systems have a significant potendal for the development of new biomedical applicadons. The wide variety of strategies reflects the inherent difficulty in transport of therapeudc and imaging agents across the BBB. In fact, the 

What ai e the main features of the BBB that restrict dnig transport to the brain  

Describe the properties of polymers that are useful for diTig delivery systems. 

List types of nanocarriers for drug delivery. Describe their stiiicture, principal differences, advantages and limitations. 

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How is the chemical modification of polypeptides with fatty acids and amphiphilic block copolymers applied to increase delivery of polypeptides to CNS ... 

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