Micelles self-assembly

To complete this overview of chain models, we mention the dimer models, which represent the amphiphiles by just two units attached to each other [153-157]. They have been used to study curved bilayers [153], the kinetics of phase separation between oil and water in the presence of surfactants [155], and some aspects of self-assembled micelles [154,157] (see below). 

Dou H, Jiang M, Peng H et al (2003) pH-dependent self-assembly micellization and micelle-hollow-sphere transition of cellulose-based copolymers. Angew Chem Int Ed 42 1516-1519... 

Zana R. Dynamics of surfactant self-assemblies micelles, microemulsions, vesicles, and lyotropic phases. New York CRC Press 2005. 

Zana, R. (ed.), Dynamics of Surfactant Self-Assemblies Micelles, Microemulsions, Vesicles and Lyotropic Phases. CRC New York, 2005. 

Lecommandoux, S., et al. (2006), Smart hybrid magnetic self-assembled micelles and hollow capsules, Prog. Solid State Chem., 34(2 4), 171-179. 

Relatively few studies on the synthesis of mesoporous alumina have been reported to date [8]. One of the limitations of the reported synthetic strategies is that the rate of hydrolysis (and condensation) reaction of aluminum alkoxide are much faster than that of silicon alkoxide. In this study, we proposed a novel method to prepare bimodal porous aluminas with meso- and macropores with narrow pore size distribution and well-defined pore channels. The fiamewoik of the porous alumina is prepared via a chemical templating method using alkyl caiboxylates. Here, self-assemblied micelles of carboxylic acid were used as a chemical template. Mesoporous aluminas were prepared through carefiil control of the reactants pH, while the procedures are reported elsewhere [9]. 

Despite the success in the fabrication of nanoceramic lines by plasma etching of aligned micellar precursors, our further exploitations of PFS nanostructures were often frustrated by the labile nature of the self-assembled micelles in that they easily undergo dissociation in a common solvent or at an elevated temperature. 

Hydrophobic attraction is also very important in understanding molecular self-assembly, micelle-formation, biological membrane structure and protein conformations, which will be discussed in Chapters 5, 7, 9 and 10. 

The shcll-crosslinking of self assembled micelles based on block copolymers made by NMP or ATRP has been exploited extensively by Wooley and coworkersand others to make a variety of structures. RAFT has also... 

Bian F, Jia L et al (2009) Self-assembled micelles of N-phthaloylchltosan-g-polyvlnylpyr-rolldone for drug delivery. Carbohydr Polym 76 454 59... 

Amphiphilic molecules such as surfactants and block copolymers containing hydrophobic (water-insoluble) and hydrophilic (water-soluble) parts, serve as simple synthetic model systems for understanding self-assembly. Micellization is a common self-assembly process whereby amphiphilic molecules spontaneously aggregate into various nanostructures that are usually of spherical, ellipsoidal, cylindrical, or vesicular shapes [1, 2]. These processes usually occur in selective solvents, i.e., solvents that are good for one part but poor for the other. Here, self-assembly is primarily driven by the incompatibility of the insoluble (hydrophobic or more generally solvophobic ) part with water or other solvents, and is mainly counteracted by repulsions or unfavorable configurations experienced in the swollen corona of the resulting micelles. 

Multi-functional micelles self-assembled from LDBCs have been developed for intracellular delivery of antitumor drugs. Self-assembled micelles of amphiphilic LDBCs comprised of semi-polyamidoamine-fe-poly(D,L-lactic acid) (PALA) were used to deliver docetaxel (DTX) to MCF-7 cells in vitro. In rat models, the DTX-loaded PALA micelles showed enhanced plasma concentrations of DTX and prolonged drug clearance in comparison to a clinically used... 

R. Zana, Dynamics of Surfactant Self-Assembly Micelles, Microemulsions, Vesicles, and Lyotropic Phases, Vol. 125, CRC Press, Boca Raton, 2005. 

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