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Polypeptide block copolymers hydrogels

Polypeptide-containing polymers can not only gel organic solvents but can also form hydrogels. First examples were polypeptide block copolymers with a hydro-phobic polypeptide block with well-defined secondary structure and a charged polypeptide block in the coil form [61, 62]. The assembly mechanism was found to occur via an association of a-helices perpendicular to the long dimensions of the... [Pg.11]

Li, K., Yu, L., Liu, X.J., Chen, C., Chen, Q.H., Ding, J.D. A long-acting formulation of a polypeptide drug exenatide in treatment of diabetes using an injectable block copolymer hydrogel. Biomaterials 34, 2834-2842 (2013)... [Pg.34]

Figure 6.7 Protein-based self-assembled nanomaterials and fabrication strategies (a) structure of coiled-coil polypeptide, (b) association of the end helices into coiled-coils results in hydrogel formation, (c) amphiphilic block copolymers assemble into extended tapered end fibers, forming hydrogels, and (d) association of two-component proteins to form a hydrogel. Modified firom Ref. [3] with permission. Figure 6.7 Protein-based self-assembled nanomaterials and fabrication strategies (a) structure of coiled-coil polypeptide, (b) association of the end helices into coiled-coils results in hydrogel formation, (c) amphiphilic block copolymers assemble into extended tapered end fibers, forming hydrogels, and (d) association of two-component proteins to form a hydrogel. Modified firom Ref. [3] with permission.

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See also in sourсe #XX -- [ Pg.177 ]




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