Polyoxyethylene-9-lauryl ether

Tomida, H., T. Yotsuyanagi, and K. Ikeda. 1978. Solubilization of benzoic acid derivatives by polyoxyethylene lauryl ether.Chem. Pharm. Bull. 26 2824-2831. 

Thus far the solvent systems we have discussed are typical protic organic media, such as, for example, water-ethanol mixtures containing an added supporting electrolyte. These solvents are presumably quite homogeneous on a microscopic level. However, a number of solvents have been developed in recent years which are heterogeneous on a microscopic scale. Micellar media are one example of such solvents. The electrochemical reduction of nitrobenzene in aqueous solutions containing polyoxyethylene lauryl ether, a substance known to produce neutral micelles, produces azobenzene (4) even at pH somewhat less than 723. This is apparently the first case of formation of a dimeric product from electrolysis of nitrobenzene (1) in acidic media. Another striking example of this phenomenon... 

Materials that are solubilized in polyethylene glycol can be solubilized in the polyoxyethylene chains on the surface of a nonionic micelle. Ismail, Gouda, and Motawi found that the micellar partition coefficients of barbiturates in polysorbates 20, 40, 60, and 80 is a function of the solute substituents and is proportional to the octanol-water partition coefficient of the barbiturate. Similarly, Ikeda, Kato, and Tukamoto showed that the solubilization of alkyl barbiturates by polyoxyethylene lauryl ether is not dependent upon the number of carbons in the substituents. Since the different polysorbates contain different aliphatic groups, the rather small dependence of solubilization upon polysorbate number (i.e., upon alkyl chain length) suggests that the barbiturates are not solubilized primarily in the hydrocarbon portion of the micelle. Gouda, Ismail, and Motawi showed that the solubilization of barbiturates in polyoxyethylene stearates is proportional to the number of polyoxyethylene units in the surfactant. 

Polyoxyethylene lauryl ether Follicular contact dermatitis (33)... 

Name Polyoxyethylene lauryl ether Sample preparation Film, potassium bromide disk... 

In these studies, the system water/Brij 30 (polyoxyethylene lauryl ether with an average of 4mol ethylene oxide/decane) was chosen as a model to obtain O/W emulsions. The results showed that nanoemulsions with droplet sizes on the order of 50 nm were formed only when water was added to mixtures of surfactant and oil (method B), whereby an inversion from a W/O emulsion to an O/W nanoemulsion occurred. 

Fluocinonide (50 mg) is dissolved in crotamiton (7 g) with warming, and thereto is added liquid paraffin (10 g), propylene glycol (10 g), polyoxyethylene lauryl ether (1 g), a 4% aqueous solution of carboxyvinyl polymer (20 g), purified water (47 g), and a 1% aqueous solution of disodium edetate (1.2 g). 

In SPE, a small amount of organic solvent or surfactant is added to collected samples to prevent adsorption to sample containers. To increase recoveries of ng 1 levels of PAHs in SPE, ACN (40%) or surfactants above their CMC can be added to samples prior to preconcentration. Solid supports, chemically modified with copper phthalocyanine trisulfonic acid derivatives for selective sorption of PAHs, have been investigated. The selective interaction is thought to be with the tt electrons of the PAHs. Brij-35, a neutral polyoxyethylene lauryl ether surfactant was added above the CMC to water samples to prevent sorption on container walls. Before preconcentration by SPE, samples were diluted to reduce the surfactant concentration to just below the CMC. Recoveries of over 90% for SPE on solids containing copper phthalocyanine trisulfonic derivatives were obtained for spiked water samples at low ngl levels, except for NAP, ACE, and FLU. Experiments repeated using a C18 SPE preconcentration sorbent gave >90% recovery for all 16 EPA PAHs, except for ACY. Examples of the use of SDB as an SPE sorbent include the online analysis of seawater from the coast of Catalonia in Spain, where no PAHs above the low ng 1 level were detected, and the analysis of leachate from coal deposits. ... 

Polarographic measurements were carried out in an acetate buffer (the assumed pH was 3.66), and concentrations of sulphate and acetate were varied in the presence of l.OOx lO M nickel nitrate and 1.09 x 10 M nitrilotriacetate at a constant ionic strength of 0.2 M (maintained with potassium nitrate). A dropping mercury electrode was used, and polyoxyethylene lauryl ether (1-2 x 10 M) was used as a maximum suppressor. Although results are reported for 15, 25 and 35°C, the assumed pH value for the buffer at 15 and 35°C is not stated. The acetate molarities were varied from 0.025 to 0.100 M at 0.03 M sulphate, and the potassium sulphate molarities were varied from 0.01 to 0.05 M at 0.05 M acetate. The results indicated that for the experimental... 

From Diaz et al. (2003). Emulsion was prepared with 5% corn oil and 95% 10 mM imidazole-acetate buffer (pH 7.0), using 17 mM Brij 35 (polyoxyethylene lauryl ether) as emulsifier. Casein hydrolysates (91 P/N, ug/mg) were obtained by trypsin hydrolysis of casein (52 P/N /tg/mg), and 86% enriched caseinophophopeptides (237 P/N /.iglmg) were prepared by precipitation of casein hydrolysates with CaClj and ethanol. 

The acid catalysed degradation of penicillins is inhibited in cationic micelles of cetyltrimethylammonium bromide (Tsuji et al., 1982) and, as expected, neither anionic micelles of sodium dodecylsulphate nor polyoxyethylene lauryl ether promote the hydroxide-ion catalysed hydrolysis of benzylpenicillin (Gensmantel and Page, 1982a). In the presence of cetyltrimethylammonium bromide (CTAB) the pseudo first-order rate constants for the alkaline hydrolysis increase rapidly with surfactant concentration once... 

Self-diffusion NMR is being applied more and more in the characterization of MEs and a few examples wiU be given in the following paragraph. Biruss et al. investigated an ME consisting of 22% (w/w) polyoxyethylene lauryl ether (Brij-30), 22% (w/w) ethanol, 45% (w/w) eucalyptus oil and 10% (w/w) distilled water for the topical delivery of various hormonal drugs [76]. 

BHT, butylated hydroxytoluene DBS, sodium dodecylbenzene sulfonate DSTDP, distearylthiodipropionate PAAE, polyamide amine epichlorohydrin PAM, polyacryl(methacrylate) PEG, polyoxyethylene lauryl ether SBR, styrene-butadiene rubber. 

Polyoxyethylene lauryl ether PEI Polyethylene imine, polyetherimide... 

Asgher et al. (2011b) have also reported another FI-CL method to determine retinol and a-tocopherol in pharmaceuticals and human blood serum based on the enhancement effect of the lucigenin CL reaction in alkaline medium. Surfactants including polyoxyethylene lauryl ether (Brij-35), Triton X-100, cetyltrimethyl ammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) enhance lucigenin CL intensity. With Brij-35, the enhancement was 67% for retinol and 58% for a-tocopherol. With CTAB, the enhancement was 16% for retinol whereas for a-tocopherol, the CL intensity was quenched by up to 95%. Retinol could be determined specifically in the presence of a-tocopherol using CTAB. 

Other polyoxyethylated glycol monoethers are commercially available as the Brij series (Atlas) which includes polyoxyethylene lauryl ethers (Brij 30, 35) cetyl ethers (Brij 52, 56, 58), stearyl ethers (Brij 72, 76, 78) and oleyl ethers (Brij 92, 96,98). 

A wider range of 34 benzoic acid derivatives has been studied in detail by Tomida et al. [27]. Using a solubility method these workers obtained saturation solubilities of the benzoic acid derivatives in Brij 35 (a polyoxyethylene lauryl ether) over a range of concentrations. Solubility ratios, calculated as the solubility in the surfactant solution/solubility in HCl, were a linear function of surfactant concentration allowing the calculation of a partition coefficient Pm which can be defined as... 

O—O polyoxyethylene lauryl ether-10 — polyoxyethylene lauryl ether-15 From Kakemi et al [141]. 

Figure 7.38 (a) and (b) The effect of non-ionic detergents on the activity of antibiotics as shown by the effect of (a) polyoxyethylene lauryl ether (CMC 0.011%) on penicillin, tetracycline, chloramphenicol, and bacitracin in concentrations ranging from 0.005 to 5.0 %, and (b) the effect of five different non-ionics on the activity of chloramphenicol (50 mg%). The critical micellar concentrations of the detergents are shown [172]. 

Figure 1.4 Plots of the interfacial tension of corn oil/surfactant solutions and detergency as a function of the number of glycerol or oxyethylene (EO) units of polyglycerol laurate (filled symbols) and polyoxyethylene lauryl ether (open symbols).

Chem. Descrip. Polyoxyethylene lauryl ether phosphate Ionic Nature Anionic... 

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