Polyoxyethylene, graft copolymer

E Bayer, M Dengler. B Hemmasi. Peptide synthesis on the new polyoxyethylene-polystyrene graft copolymer, synthesis of insulin B21.30. btt J Pept Prot Res 25, 178, 1985. 

In this review we summarize and discuss the amphiphilic properties of polyoxyethylene (PEO) macromonomers and PEO graft copolymer molecules, the aggregation of amphiphilic PEO macromonomers into micelles, the effect of organized aggregation of macromonomers on the polymerization process, and the kinetics of radical polymerization and copolymerization of PEO macromonomer in disperse (dispersion, emulsion, miniemulsion, microemulsion, etc.) systems [1-5]. 

Several groups have attempted the anchoring of ketone catalysts for use in combination with Oxone (404-407). One of the incentives for anchoring the catalyst is that the most suitable ketone, 1,1,1-trifluoroacetone, is highly volatile. A solid-bound, nonvolatile ketone therefore offers obvious handling and cost advantages. In one approach, 4-(trifluoroacetyl)benzoic acid was anchored to a graft copolymer of polystyrene and polyoxyethylene (17a) (406) alternatively, aliphatic ketones were covalently bound to silica (17b) (405, 407). 

Watanabe62) studied systematically the copolymerization of ra-methacryloyl-polyoxyethylenes, with monomers such as acrylonitrile, styrene, butyl methacrylate, and methacrylic acid. It should be mentioned that the macromonomers that he prepared are very short so that no difficulties were encountered to isolate the graft copolymers formed. There are many applications for these graft copolymers, e.g. as additives in polyacrylonitrile films and fibers they cause improved antistatic properties. They have been tested as varnishes, coatings, and wood dimensional stabilization agents. 

Most synthetic methods for the generation of peptide libraries have been derived from various multiple parallel peptide synthesis techniques developed since 1984.bs-i l Consequently, the sohd supports used for hbrary synthesis are essentially the same as those used for multiple peptide synthesis. Standard divinylbenzene cross-linked polystyrene resins are typically used for hbraries that are cleaved from the resin and screened in solution.P Polyoxyethylene-grafted polystyrene resins,f l or acrylamide-polyoxyethylene copolymers, P on the other hand, are the sohd supports of choice for the synthesis of resin-bound peptide hbraries screened in sohd-phase binding assays.P Such resins are compatible with both organic solvents used for peptide synthesis, as well as aqueous buffers used in the bioassays. Various segmental supports previously employed for multiple peptide syntheses have also been utilized for the synthesis of peptide libraries, including polypropylene pins, PI cotton,t cellulose membrane,and glass shdes.P ... 

CAS 64365-23-7 68937-54-2 68938-54-5 Synonyms Dimethylmethyl (polyethylene oxide) siloxane Dimethylsilox-ane/glycol copolymer Polyoxyethylene-grafted polydimethylsiloxane Polysiloxane polyether copolymer Siloxanes and silicones, dimethyl, hydroxy-terminated, ethoxylated propoxylated Classification Silicone glycol surfactant... 

The graft copolymer thus obtained was extracted with cyclohexane three times, each for 24 hours, so as to remove unreacted polystyrene. After vacuum drying, it was extracted three times (each lasting 24 hrs) with 20% aqueous solution of ethyl alcohol, in order to remove polyoxyethylene homopolymer. Phenyl content of the graft copolymer and the extracts were measured by a 730 Ultraviolet Spectrophotometer. IR spectra were obtained by a Perkin-Elmer 580B Spectrophometer. 

A typical example of graft copolymers is that recently published by Winnik and co-workers [309]. These authors have studied the solubilization of cyclosporine A, as a model drug, in micellar systems based on hydroxypropylcellulose-g-polyoxyethylene alkyl ether. They could demonstrate that the drug loading in the micelles, with diameters ranging from 78 to 90 nm, increases with the number of grafted chains. 

Tg measurements have been performed on many other polymers and copolymers including phenol bark resins [71], PS [72-74], p-nitrobenzene substituted polymethacrylates [75], PC [76], polyimines [77], polyurethanes (PU) [78], Novolac resins [71], polyisoprene, polybutadiene, polychloroprene, nitrile rubber, ethylene-propylene-diene terpolymer and butyl rubber [79], bisphenol-A epoxy diacrylate-trimethylolpropane triacrylate [80], mono and dipolyphosphazenes [81], polyethylene glycol-polylactic acid entrapment polymers [82], polyether nitrile copolymers [83], polyacrylate-polyoxyethylene grafts [84], Novolak type thermosets [71], polyester carbonates [85], polyethylene naphthalene, 2,6, dicarboxylate [86], PET-polyethylene 2,6-naphthalone carboxylate blends [87], a-phenyl substituted aromatic-aliphatic polyamides [88], sodium acrylate-methyl methacrylate multiblock copolymers [89], telechelic sulfonate polyester ionomers [90], aromatic polyamides [91], polyimides [91], 4,4"-bis(4-oxyphenoxy)benzophenone diglycidyl ether - 3,4 epoxycyclohexyl methyl 3,4 epoxy cyclohexane carboxylate blends [92], PET [93], polyhydroxybutyrate [94], polyetherimides [95], macrocyclic aromatic disulfide oligomers [96], acrylics [97], PU urea elastomers [97], glass reinforced epoxy resin composites [98], PVOH [99], polymethyl methacrylate-N-phenyl maleimide, styrene copolymers [100], chiral... 

Sun and coworkers (181) used a different approach to prepare block copolymers. A polyoxyethylene with a terminal allyl group was reacted with acrylic acid to produce a graft copolymer polyoxyethylene-g-poly (acrylic acid). 

Xie H Q and Xie D (1999) Molecular design, synthesis and properties of block and graft copolymers containing polyoxyethylene segments, Progr Polym Sci 24 275-313. 

Figure 6.1 7 Structure of a graft-type silicone-polyoxyethylene copolymer, MD (D EOxOH)mM.

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