Polymorphism detection

Hameed AAA, Jean N, Stephen O, Andy PM (2008) Improved single nucleotide polymorphisms detection using conjugated polymer/surfactant system and peptide nucleic acid. Biosens Bioelectron 23 1466-1472... 

Wang YS, Liu B (2007) Label-free single nucleotide polymorphism detection using a cationic tetrahedralfluorene and silica nanoparticles. Anal Chem 79 7214-7220... 

The application of Raman spectroscopy in primary manufacturing was reviewed by Fevotte [25] who put a special emphasis on crystallisation monitoring. It includes tables of typical applications in crystallisation monitoring and other transient processes, respectively. The author concludes that several open questions such as better calibration procedures, dependence on size distribution and sampling techniques need to be addressed before we will see a wider use of Raman spectroscopy in pharmaceutical manufacturing applications. Yu et al. [26] presented a broader review of crystallisation control including in-line Raman for polymorph monitoring. The authors discuss future developments needed for the respective techniques and point out the potential of Raman spectroscopy for in-line polymorph detection. 

Because the number of polymorphisms detected is primarily limited by the number of primers tested, it is often possible to identify more polymorphisms than are needed for a particular study. Therefore, the best... 

Kohler O, Jarikote DV, Seitz O. Forced Intercalation Probes (FIT Probes) Thiazole orange as a fluorescent base in peptide nucleic 39. acids for homogeneous single-nucleotide-polymorphism detection. ChemBioChem. 2005 6 69-77. 

ADMET Properties of Drugs Cytochrome P450 Monooxygenases, Chemistry of Drug Metabolizing Enzymes, Chemistry of Enzyme Inhibition, Chemistry and Mechanisms of Polymorphisms, Detection of... 

Inouye M, Ikeda R, Takase M, Tsuii T, Chiba J (2005) Single-nucleotide polymorphism detection with wire-like DNA probes that display quasi on-ofF digital action. Proc Natl Acad SciUS A102 11606-11610... 

B. Fiszer-Szafarz. Hyaluronidase polymorphism detected by polyacrylamide gel electrophoresis. Application to hyaluronidases from bacteria, slime molds, bee and snake venoms, bovine testes, rat liver lysosomes and human serum. Anal. Biochem. 143 16 (1984). 

Single-strand conformational polymorphism detection methodology... 

Curran, S., Hill, L., O Grady, G., et al. (2002) Validation of single nucleotide polymorphism (SNP) quantification in pooled DNA samples using SNaPlT technology, a glycosylase-mediated polymorphism detection method. Biotechniques 21, 253-262. 

Not all instances of conformational polymorphism are as dramatic as that just described, and often different conformers of a single side chain are able to pack into different crystalline arrangements. For instance, the two polymorphs of/>-(li ,3 S)-3-thioanisoyl-l,2,2-trimethyl-cyclopentane carboxylic acid were found to be associated with different conformations of the carboxylate group [15], Torsion about a single C-N bond was shown to be the origin of the polymorphism detected for lomeridine dihydrochloride [16], Finally, relatively small differences in molecular conformation were detected for the two polymorphic and four solvated crystalline forms of spironlactone [17],... 

Kasuga T, Cheng J, Mitchelson KR (1995). Metastable single-strand DNA conformational polymorphism analysis results in enhanced polymorphism detection. PCR Methods AppL, 4 227-233. 

Yilmaz A, Davis ME, Hines HC (1999). APCR-SSCP polymorphism detected in the 5 flanking region of the ovine IGF-I gene, http //ohioline.osu.edu/scl70/scl70 18.html. 

Nei, M. and F. Tajima 1981 DNA polymorphism detectable by restriction endonucleases. Genetics SHi 145-163. 

Maruyama, K. Takeyama, H. Nemoto, E. Tanaka, T. Yoda, K Matsunaga, T. (2004), Single nucleotide polymorphism detection in aldehyde dehydrogenase 2 (ALDH2) gene using bacterial magnetic particles based on dissociation curve analysis. 

S. Purushothaman, C. Toumazou, C.-P. On, Protons and single nucleotide polymorphism detection a simple use for the Ion Sensitive Field Effect Transistor, Sensors and Actuators B Chemical 114 (2006) 964-968. 

Cancer diagnostics often needs a discrimination of genomic mutations in DNA sequences or special NA structures (miRNA) which can cause various diseases including cancer. SERS technique is very promising for mutation and single nucleotide polymorphisms detection because of the possibility of spatial multiplexing at array format linked with a portable biosensor device. Mahajan and co-workers reported such SERS-based approach using Au substrates prepared by... 

Kurose, K. Komori, M. SLC28A1/A2/A3 gene polymorphism detection probe. Jpn. Kokai Tokkyo Koho JP 2013094116, 2013. 

Landry, B.S., Hubert, N., Etoh, T., Harada, J.J., Lincoln, S.E., 1991. A genetic map for Brassica napus based on restriction fragment length polymorphisms detected with expressed DNA sequences. Genome 34, 543—552. 

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