Macromolecules, polymeric drug delivery systems

Brown, L.R., C.L. Wei, and R. Langer, In vivo and in vitro release of macromolecules from polymeric drug delivery system. Journal of Pharmaceutical Research, 1983,72, 1181-1185. 

The copolymer-based systems possessing the core-shell structure in solutions are known and studied rather well (see, e.g., [14-16]). These copolymers in aqueous media tend to form polymeric micelles, which are often considered as promising drug delivery nano-vehicles [ 17,18], i.e., these macromolecular systems are not only of scientific, but also of considerable applied significance. Among such systems there are interesting examples, whose properties are very similar to the properties that should be inherent in the protein-like copolymers. All of these macromolecules possess the primary structure of... 

---