Polymeric drug delivery

Figure 6 also shows that the use of this polymeric delivery system, also known as the BIODEL polymeric drug delivery system, for BCNU greatly increases the time over which the brains of these animals are exposed to significant BCNU concentrations. The brains... [Pg.53]

Polymeric drugs—Congresses. 2. Polymeric drug delivery... [Pg.4]

This book is divided into four sections that cover the main topics in the field of drug delivery. The first section gives an overview of the polymers and materials currently being used in drug delivery and some of the problems with and opportunities for polymeric drug delivery. The overview chapters are followed by a section on polymeric drugs and polymer-drug... [Pg.7]

Interactions between Polymeric Drug Delivery Systems and Biological Systems Barriers and Opportunities... [Pg.40]

In general, the performance of any polymeric drug delivery system is highly dependent on both the therapeutic result desired and the milieu in which the system must operate. Both of these considerations are set by the interaction between the delivery system and the biological system in which it must operate. Most drug delivery systems, then, are intended to achieve one of the following three goals ... [Pg.40]

In this chapter an overview of both the opportunities and the problems presented by the biological system for the use of polymeric drug delivery systems will be presented. Since the area of biocompatibility of the delivery system is a well-known constraint also imposed by the biological system and is beyond the scope of this presentation, this (important) consideration will be ignored here. In order to examine how a delivery system interacts with the biological system to... [Pg.40]

Two basic questions arise from the biological system (excluding the route of administration discussed above) when the use of a polymeric drug delivery system is contemplated ... [Pg.42]

In this brief overview some considerations with respect to the biological system vis-a-vis polymeric drug delivery have been qualitatively presented. Delivery systems can be designed to either overcome a barrier or take advantage of a property associated with a route of administration. Once introduced into a biological system, a delivery system s operation must be consistent with the operation of the biological system to achieve the desired goal based on temporal release pattern. [Pg.44]

Finally, site-specific delivery also depends on the extent of competing processes in the biological system as well as the interaction of the drug itself with the biological system. Therefore successful design of polymeric drug delivery approaches requires a comprehensive appreciation of the pharmacology, pharmacokinetics, and pharmacodynamics involved. [Pg.44]

In this paper, then, the previously developed model (7) is extended to the calculation of erosion characteristics of a well described polymeric delivery system, the acid-catalyzed erosion of poly (ortho ester)s (2-6). This system is chosen as the example system because of the completeness of the data package in the open literature. It is expected that this modelling approach is also useful for other hydrolytically unstable polymeric drug delivery systems. [Pg.171]

A mathematical model has been developed which allows the calculation of the degradation of polymeric drug delivery systems. The model has been shown to accurately simulate both the drug release and molecular weight changes in such systems. The concentration of anhydride levels affect the erosion characteristics of... [Pg.176]

Figure 1 Schematic illustration of an ideal stimuli-modulated polymeric drug delivery system.

Polymeric drug delivery systems, for cancer treatment, 9 82... [Pg.734]

In this study, we demonstrate new pH/temperature-sensitive polymers with transitions resulting from both polymer-polymer and polymer-water interactions and their applications as stimuli-responsive drug carriers [22-23], For this purpose, copolymers of (Ai,Ai-dimethylamino)ethyl methacrylate (DMAEMA) and ethylacrylamide (EAAm) [or acrylamide (AAm)] were prepared and characterized as polymeric drug delivery systems modulated for pulsatile and time release. [Pg.51]

Shibaev, V. and Lam, L. 1993. Liquid Crystalline and Mesomorphic Polymers. Springer, New York. Svenson, S. 2006. Polymeric Drug Delivery I and II. Oxford University Press, New York. [Pg.623]

Polymeric Drug Delivery Systems, edited by Glen S. Kwon... [Pg.549]

L.R.Brown, C.L.Wei and R.Langer,/ vivo and in v/ft-o release of macromolecules from polymeric drug delivery... [Pg.191]

Another driver for novel polymer research was the increasing complexity of polymeric drug delivery systems. An ideal polymer for these applications should serve the following requirements ... [Pg.347]

Jacob, J.S., et al., Polymeric drug delivery system for hydrophobic drugs, US patent application 20050249799, published on November 10, 2005. [Pg.636]

Weiner, A.L. 1994. Polymeric drug delivery systems for the eye. In Polymeric site-specific pharmacotherapy, ed. A.J. Domb, 315-346. Chichester Wiley. [Pg.521]

Liu Y, Wenning L, Lynch M et al (2006) Gene delivery with novel poly(L-tartaramidoamine) s. In Svenson S (ed) Polymeric drug delivery, volume I particulate drug carriers. American Chemical Society, Washington DC, pp 217-227... [Pg.188]

M. Hashida and Y. Takakura. Pharmacokinetics in design of polymeric drug delivery systems. J. Control. Release 31 163—171, 1994. [Pg.38]

Polymeric drug delivery system HPLC Precolumn C CH,CN oOmA/PO,. 340 nm Method review [674]... [Pg.215]

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