Injectable polymeric carriers for gene delivery systems

Key words pol5Tners, biodegradable, poly(ester aminejs, transfection 

Polymeric carriers can be divided into three groups according to the administration routes site specific, local and systemic carriers. Following the 

Polyplexes face various extracellular as well as intraeellular barriers. Most of the extracellular barriers are the factors that influence biodistribution of the administered polyplexes from the point of delivery to the site of interest and they will vary profoundly between routes of delivery. 

1 (a) Particle sizes of PCL/PEI-1.2/DNA complexes at various N/p ratios, (b) zeta potential measurement and (c) atomic force microscopy images of PCL/PEI-1.2/DNA complexes at N/P ratio 10 (error bars represent standard deviation) (cited from Ref. 38). 

Hyperosmotic biodegradable GDM/PEI and GTA/PEI also revealed superior gene expression in lungs, after aerosol administration. The increased reporter gene expression shown by the glycerol-based PEAs over the other PEAs is due to the hyperosmotic effect that it exerts because of the presence of glycerol 

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Injectable polymeric carriers for gene delivery systems 237... 

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