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Biodegradable polymeric delivery system

Natural/Biodegradable Polymeric Delivery Systems 5.1. Collagen... [Pg.22]

Several of the most effective polymeric delivery systems were polyamidoamine den-drimers (220) and polyethyleneimines (PEI) (221). Being non-biodegradable, these synthetic polymers posed a potential toxicity to cell therefore, biodegradable polypeptides like PLL and protamine were used for condensation and delivery of gene, but they had limited efficacy in transfection (222, 223). They were usually used with cationic lipids to obtain enhanced transfection activity (178,201). Among the biodegradable polymers, chitosan... [Pg.668]

The Norplant device has been somewhat controversial, however, due to difficulties associated with its removal. A second example of an implantable drug delivery system is Zoladex, which is an implantable biodegradable lactide/glycolide polymeric delivery system for the administration of goserelin acetate. It is available in one-month and three-month presentations and can be injected through a wide-bore needle. [Pg.346]

DeLuca, P.P., et al., Biodegradable polyesters for drug and polypeptide delivery, in M.A. El-Nokaly, D.M. Piatt, and B.A. Charpentier. Polymeric Delivery Systems Properties and Applications. Washington, DC American Chemical Society, 1993, pp 53-79,... [Pg.344]


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See also in sourсe #XX -- [ Pg.382 ]




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