Polymeric drug delivery system-biological

Interactions between Polymeric Drug Delivery Systems and Biological Systems Barriers and Opportunities... 

In general, the performance of any polymeric drug delivery system is highly dependent on both the therapeutic result desired and the milieu in which the system must operate. Both of these considerations are set by the interaction between the delivery system and the biological system in which it must operate. Most drug delivery systems, then, are intended to achieve one of the following three goals ... 

In this chapter an overview of both the opportunities and the problems presented by the biological system for the use of polymeric drug delivery systems will be presented. Since the area of biocompatibility of the delivery system is a well-known constraint also imposed by the biological system and is beyond the scope of this presentation, this (important) consideration will be ignored here. In order to examine how a delivery system interacts with the biological system to... 

Two basic questions arise from the biological system (excluding the route of administration discussed above) when the use of a polymeric drug delivery system is contemplated ... 

In this brief overview some considerations with respect to the biological system vis-a-vis polymeric drug delivery have been qualitatively presented. Delivery systems can be designed to either overcome a barrier or take advantage of a property associated with a route of administration. Once introduced into a biological system, a delivery system s operation must be consistent with the operation of the biological system to achieve the desired goal based on temporal release pattern. 

Finally, site-specific delivery also depends on the extent of competing processes in the biological system as well as the interaction of the drug itself with the biological system. Therefore successful design of polymeric drug delivery approaches requires a comprehensive appreciation of the pharmacology, pharmacokinetics, and pharmacodynamics involved. 

Z. R. Lu, J. G. Shiah, P. Kopeckovd and J. Kopebek, Preparation and biological evaluation of polymerizable antibody Fab fragment targeted polymeric drug delivery system, /. Control. Release, 74, 263-268 (2001). 

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