Polyethylene glycol-modified

Acid-catalyzed matrices, kinetics of controlled release, 170-179 Active targeting, definition, 276 Adenosine deaminase, activity of polyethylene glycol modified enzymes, 98-99 Adjuvax... 

ADA deficiency is most commonly associated with these mutations of the ADA structural gene that result in either unstable or inactive enzyme protein. Immune reconstitution would be achieved by enzyme replacement therapy with polyethylene glycol-modified bovine ADA (PEG-AD A), alone or in combination with gene therapy (H3). 

Wang, P., Woodward, C.A., and Kaufman, E.N., Polyethylene glycol)-modified ligninase enhances pentachlorophenol biodegradation in water-solvent mixtures, Biotechnol. Bioeng., 64, 290-297, 1999. 

Inada, Y., Takahashi, K., Yoshimoto, T., Ajima, A., Matsushima, A., and Saito, Y. (1986) Applications of polyethylene glycol-modified enzymes in biotechnological processes Organic solvent-soluble enzymes. Trends Biotechnol. 4, 190-194. 

Tabata Y, Murakami Y, Ikada Y (1997) Photodynamic effect of polyethylene glycol-modified fullerene on tumor. Jpn J Cancer Res 88 1108-1116. 

Phillips W, Klipper R, Awasthi V, et al. Polyethylene glycol-modified liposome-encapsulated hemoglobin a long circulating red cell substitute. J Pharmacol Exp Ther 1999 288 665. 

Winslow R, Kramer G. Maleimide-polyethylene glycol-modified human hemoglobin. Crit Care Med 2003 31 2815. 

Keywords Immobilization Thermoregulated catalysis Thermomorphic ligands Hydroformylation Polyethylene glycol modified phosphites... 

Modification of phospholipids by modified lipase. Phospholipids are natural emulsifiers which have many applications in foods, cosmetics, pharmaceutical and other industries. Yagi et ai (5) reported the transesterification of phospholipids with native lipase. Yoshimoto et al, (6) reported the transesteritication of phospholipids with polyethylene glycol modified lipase. 

Lipase has been used in organic solvents to produce useful compounds. For example, Zark and Klibanov (8) reported wide applications of enzymes to esterification in preparing optically active alcohols and acids. Inada et al (9) synthesized polyethylene glycol-modified lipase, which was soluble in organic solvent and active for ester formation. These data reveal that lipases are very useful enzymes for the catalysis different types of reactions with rather wide substrate specificities. In this study, it was found that moditied lipase could also synthesize esters and various lipids in organic solvents. Chemically moditied lipases can help to solve today s problems in esteritication and hopefully make broader use of enzymatic reactions that are attractive to the industry. 

Hershfield, M.S., R.H. Buckley, M.L. Greenberg, A.L. Melton, R. Schiff) C. Hatem, J. Kurtzberg, M.L. Markert, R.H. Kobayashi, A.L. Kobayashi, et al., Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase. N Engl J Med, 1987. 316(10) 589-96. 

T-lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase. Weinberg, K., Hershfield, M.S., Bastian, J., Kohn, D., Sender, L., Parkman, R., Lenarsky, C. (1993).JClin Invest, 2 596-602. 

Scheme 18.4 Photoinduced Hydrogen evolution using polythylene glycol modified chlorophyll and hydrogenase. RSH 2-mercaphoethanol FEG-Chl polyethylene glycol modified chlorophyll MV2+ metnylviologen, H2ase nydrogenase...

Beer (ADH)/entrapped in carbon polyethylene glycol-modified / -naphtamido-... 

Q. Yao, S. Yabuki and F. Mizutani, Preparation of a carbon paste/alcohol dehydrogenase electrode using polyethylene glycol-modified enzyme and oil-soluble mediator, Sens. Actuators B Chem., 65(1-3) (2000) 147-149. A. Morales, F. Cespedes, E. Martinez-Fabregas and S. Alegret, Ethanol amperometric biosensor based on an alcohol oxidase-graphite-polymer biocomposite, Electrochim. Acta, 43(23) (1998) 3575-3579. 

Wheeler, J. J., Wong, K. F., Ansell, S. M., et al. Polyethylene glycol modified phospholipids stabilize emulsions prepared from triacylglycerol. Pharm. Res. 83 1558-1564, 1994. 

Levy, Y., Hershfield, M. S., Fernandez-Mejia, C., et al. Adenosine deaminase deficiency with late onset of recurrent infections Response to treatment with polyethylene glycol-modified adenosine deaminase. J. Pediatr. 113(2) 312-317. 1988. 

T. Yosiumoto, H. Nishimun, Y.Saito.etal. Characterization of polyethylene glycol-modified 1-asparaginase from Escherichia coli and its application to therapy of lEUksnhJpn. J. Cancer Ret. 77 1264 (1986). 

Tabata, Y., et al. (1997), Antitumor effect of polyethylene glycol)-modified fullerene, Fullerene Sci. Technol., 5, 989-1007. 

Price, M. E., Cornelius, R. M., and Brash, J. L. (2001), Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma, Biochim. Biophys. Acta, 1512,191-205. 

Bruin GJM, Chang JP, Kuhlman RH, Zegers K, Kraak JL, Poppe H (1989) Capillary zone electrophoretic separation of proteins in polyethylene glycol-modified capillaries. J Chromatogr 471 429-436. 

Nakai, K. Usuba, A. Ohta, T. Kuwabara, M. Nakazato, Y. Motoki, R. Takahashi, T.A. Coronary vascular bed perfusion with a polyethylene glycol-modified hemoglobin-encapsulated liposome, neo red cell, in rats. Artif. 

Sakai, H. Tsai, A.G. Intaglietta, M. Tsuchida, E. Hemoglobin encapsulation with polyethylene glycol-modified and unmodified vesicles systemic and microvascular hemodynamics at 80% blood substitution. In Advances in Blood Substitutes Industrial Opportunities and Medical Challenges Winslow, R.M., Vandegriff, K.D., Intaglietta, M., Eds. Birkhauser Boston, 1997 151-166. 

The use, benefits, and adverse effects of aldesleukin in HIV-infected patients have been extensively reviewed (8). Aldesleukin significantly increased the CD4+ cell count without an increase in viral load. However, many questions remain unanswered. In particular, it is still not known whether immunological improvements translate into clinical benefit. Regardless of how aldesleukin is administered—intravenously, subcutaneously, or as polyethylene glycol-modified (pegylated) aldesleukin— adverse effects are generally not treatment-limiting. As the duration of adverse effects was shorter with the subcutaneous route, these patients may be treated as outpatients (9). 

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