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Polyethylene glycol-modified enzyme properties

Abuchowski, A., Kazo, G.M., Verhoest Jr., C.R., van Es, T., Kafkewitz, D., Nucci, M.L., Viau, A.T., and Davis, F.F. (1984) Cancer therapy with chemically modified enzymes. Anti-tumor properties of polyethylene glycol asparaginase conjugates. Cancer Biochem. Biophys. 7, 175-186. [Pg.1041]

The modification of enzyme by attaching ions or molecules is a suitable way for providing it with useful fimctions. For example, the use of modifiers such as polyethylene glycol (PEG) (7,2) and synthetic lipids (i) enhances the affinity for hydrophobic environments. PEG-modified enzymes are soluble and active in various organic solvents as well as aqueous solutions (7,2). Lipid-modified enzymes are insoluble in aqueous solutions, but show catal c activities in both aqueous and organic media (i). These unique properties lead us to apply PEG- and lipid-modified enzymes in the construction of enzyme electrodes. [Pg.41]

See other pages where Polyethylene glycol-modified enzyme properties is mentioned: [Pg.318]    [Pg.318]    [Pg.215]    [Pg.100]    [Pg.614]    [Pg.834]    [Pg.326]    [Pg.364]    [Pg.48]    [Pg.478]    [Pg.250]    [Pg.1709]   
See also in sourсe #XX -- [ Pg.43 ]



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