Polycyclic aromatic hydrocarbons toxicology

Li, C-H, Lee, C-C, Cheng, Y-W, Juang, H-A Kanga, J-J (2004). Activation and up-regulation of nitric oxide synthase in human umbilical vein endothelial cells by polycyclic aromatic hydrocarbons. Toxicology Letters, 151, 367-374. 

Mix MC. 1984. Polycyclic aromatic hydrocarbons in the aquatic environment Occurrence and biological monitoring. In Hodgson E,ed. Reviews in environmental toxicology I. New York, NY Elsevier Science Publishers B. V., 51-102. 

Monteiro, P.R.R., Reis-Henriques, M.A., and Coimbra, J. (2000b). Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder Platichthys flesus L). Aquatic Toxicology 48, 549-559. 

Committee on Pyrene and Selected Analogues, Board on Toxicology and Environmental Health Hazards, National Research Council. "Polycyclic Aromatic Hydrocarbons Evaluation of Sources and Effects" National Academy Press Washington, D.C., 1983. 

Neff, J.M. 1985. Polycyclic aromatic hydrocarbons. Pages 416 454 in G.M. Rand and S.R. Petrocelli (eds.). Fundamentals of Aquatic Toxicology. Hemisphere, New York. 

U.S. Public Health Service (USPHS). 1995. Toxicological Profile for Polycyclic Aromatic Hydrocarbons (PAHs) (Update). U.S. Dept. Health Human Serv., USPHS, Agen. Toxic Subst. Dis. Regis. 468 pp. 

Karp, J.M., Rodrigo, K.A., Pei, P., Pavlick, M.D., Andersen, J.D., McTigue, D.J., Fields, H.W. and Mallery, S.R. (2005) Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues. Toxicology Letters, 158, 50-60. 

Sovadinova, I., Blaha, L., Janosek, J., Hilscherova, K., Giesy, J.P., Jones, P.D. and Holoubek, I. (2006) Cytotoxicity and aryl hydrocarbon receptor-mediated activity of N-heterocydic polycyclic aromatic hydrocarbons structure-activity relationships. Environmental Toxicology and Chemistry, 25, 1291-1297. 

Table 6.1 Toxicological Evaluation of Polycyclic Aromatic Hydrocarbons (PAHs) with Microtox Basic Test and Mutatox. Reprinted with permission from the American Petroleum Institute (Huckins et al., 2002)...

There is no medical test that shows if you have been exposed to fuel oils. There are methods to determine if your blood contains some fuel oil components such as benzene, toluene, and xylenes however, the concentrations of these compoimds in distilled fuels are so low that if they were detected in your blood, it might not indicate specific or exclusive exposure to fuel oils. For information on tests for measuring exposure to some individual components of fuel oils, see the ATSDR toxicological profiles on benzene, toluene, total xylenes, and polycyclic aromatic hydrocarbons. See Chapters 2 and 6 for information on symptoms that suggest exposure to fuel oils. 

ATSDR. 1991b. Toxicological profile for polycyclic aromatic hydrocarbons. Atlanta, GA U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. 

Lampi, M.A., Gurska, J., Huang, X.D., Dixon, D.G. and Greenberg, B.M. (2007) A predictive quantitative structure-activity relationship model for the photoinduced toxicity of polycyclic aromatic hydrocarbons to Daphnia magna with the use of factors for photosensitization and photomodification. Environmental Toxicology and Chemistry/SETAC, 26, 406-415. 

Bossert, I. Bartha, R. (1986). Structure-biodegradability relationships of polycyclic aromatic hydrocarbons in soil. Bulletin of Environmental Contamination and Toxicology, 37, 490-5. 

Heitkamp, M. A. Cerniglia, C. E. (1987). The effects of chemical structure and exposure on the microbial degradation of polycyclic aromatic hydrocarbons in freshwater and estuarine ecosystems. Environmental Toxicology and Chemistry, 6, 535—46. 

DENNIS M J, MASSEY R C, MCWEENY D J, KNOWLES M E and WATSON D Analysis of polycyclic aromatic hydrocarbons in UK total diets , Food and Chemical Toxicology, 1983 21 569-574. 

DE VOS R H, VAN DOKKUM W, SCHOUTEN A and DE JONG-BERKHOUT P Polycyclic aromatic hydrocarbons in Dutch total diet samples (1984-1986) , Food and Chemical Toxicology, 1990 28 263-268. 

McCarthy, J. F., and B. D. Jimenez. 1985. Reduction in bioavailability in bluegills to polycyclic aromatic hydrocarbons bound to dissolved humic materials. Environmental Toxicology... 

Discuss what the following shows about the toxicological chemistry and toxicity of some important polycyclic aromatic hydrocarbons ... 

Riddick DS, Lee C, Bhathena A, Timsit YE. The 2001 Veylien Henderson Award of the Society of Toxicology of Canada. Positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons. Can J Physiol Pharmacol 2003 81 59-77. 

Kaiser, K.L.E., Dixon, D.G., Hodson, PV. (1984) QSAR studies on chlorophenols, chlorobenzenes and para-substituted phenols. In QSAR in Environmental Toxicology. Kaiser, K. L. E., Ed., pp. 189-206, D. Reidel Publishing Co., Dordrecht, The Netherlands. Kamlet, M.J., Doherty, R.M., Carr, P.W., Mackay, D., Abraham, M.H., Taft, R.W. (1988) Linear solvation energy relationship. 44. Parameter estimation rules that allow accurate prediction of octanol/water partition coefficients and other solubility and toxicity properties of polychlorinated biphenyls and polycyclic aromatic hydrocarbons. Environ. Sci. Technol. 22, 503-509. Kanazawa, J. (1981) Measurement of the bioconcentration factors of pesticides by fresh-water fish and their correlation with physicochemical properties of acute toxicities. Pest. Sci. 12, 417-424. 

---