Polyalkylcyanoacrylate nanoparticles

Chavany, C. Ledoan, T. Couvreur, P. Puisieux, F. Helene, C. Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides. Pharm. Res. 1992, 9, 441 49. 

Page-Clisson, M.E. Pinto-Alphandary, H. Chachaty, E. Couvreur, P. Andremont, A. Drug targeting by polyalkylcyanoacrylate nanoparticles is not efficient against persistent salmonella. Pharm. Res. 1998, 15, 544-549. 

Caspar, R. Opperdoes, F.R. Preat, V. Roland, M. Drug targeting with polyalkylcyanoacrylate nanoparticles—in vitro activity of primaquine-loaded nanoparticles against intracellular leishmania-donovani. Ann. Trop. Med. Parasitol. 1992, 86, 41-49. 

Fernandez-Urrusuno, R. Fattal, E. Porquet, D. Feger, J. Couvreur, P. Evaluation of hver toxicological effects induced by polyalkylcyanoacrylate nanoparticles. Toxicol. Appl. Pharmacol. 1995,130, 272-279. 

Gibaud, S. Rousseau, C. Weingarten, C. Eavier, R. Douay, L. Andreux, J.P. Couvreur, P. Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte-colony stimulating factor (G-CSE). J. Controlled Release 1998, 52, 131-139. 

Ocular distribution and elimination of biodegradable polyalkylcyanoacrylate nanoparticles has been examined in a number of reports. " " Pilocarpine containing polybutylcyanoacrylate nanoparticles alone or in gel type formulations are capable of enhancing and prolonging the miosis and pressure lowering response in various animal models. ... 

Another kind of synthetic biodegradable microspheres used for M phagocytosis are polyalkylcyanoacrylate nanoparticles with a diameter smaller than 0.3 pm. They... 

Gipps, E.M. et al.. The effects of polyalkylcyanoacrylate nanoparticles on human normal and malignant mesenchymal cells in vitro, Int. J. Pharm., 40, 23, 1987. 

In polyalkylcyanoacrylate nanoparticles, CyDs are able to slightly decrease the toxic effect induced by polymer degradation on Caco-2 cells [42]. However, saquinavir-loaded CyD nanospheres are not able to promote the transport of this drug through Caco-2 cell monolayers [104]. In contrast, HP-j8-CyD is useful in metoclopramide-loaded nanopartides, where it enhances the absorption of meto-clopramide by a factor of 2 after subcutaneous administration in rat [43]. 

Schwab, G., Chavanv, C., Duroux, I., Goubin, G., Lebeau, J., Helene, C. and Behmoaras, T.S. (1994) Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice. Proc. Natl. Acad. Sci. t/571., 91, 10460-10464. 

Cruz T, Gaspar R, Donato A, Lopes C (1997) Interaction between polyalkylcyanoacrylate nanoparticles and peritoneal macrophages MTT metabolism, NBT reduction, and NO production. Pharm Res 14(l) 73-79... 

Couvreur P, Vauthier C (1991) Polyalkylcyanoacrylate nanoparticles as drug carrier Present state and erspectives. J. Contr. Release. 17(2) 187-198. 

Parameters such as size, density and molecular weight will influence the release of the carried dmg. Due to their small size, nanoparticles degrade faster than larger microspheres. Degradation of the nanoparticles can occur either by erosion of the polymer backbone or cleavage of the ester bonds, for example in the case of the polyalkylcyanoacrylate nanoparticles. The mechanism... 

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