Poly y-glutamic acid

Poly(7-glutamic acid) is an edible polypeptide excreted by certain bacteria that is presently accessible on a semi-industrial scale (28). Chemically, it is a nylon 4 derivative bearing a carboxylic side group attached to the fourth carbon of the repeating unit. [Pg.95]

Although this biopol5mier is being exploited in the food, agriculture and cosmetic sectors, its use in massive applications as packaging or coating is still unknown mainly because to its instability in wet environments and imsuitabUity to be processed by common techniques. [Pg.95]

Chemical modification of poly(7-glutamic acid) involving esterification or amidation of the carboxylic group is an approach to obtain materials with potential interest as fibers, films or hydrogels. Electrostatic coupling of poly(7-glutamic acid) with hydrophobic cationic species may also be profited to generate non water soluble stable derivatives. [Pg.95]

On the other hand, the interest of modified poly(y-glutamic acid) as a functionalized biomaterial for scaffold and drug delivery has considerably increased in the last years (28). [Pg.95]

Keyword Adjuvant Biodegradable nanoparticles Poly(y-glutamic acid) Protein delivery Vaccine... [Pg.32]

Matsusaki M, Hiwatari K, Higashi M et al (2004) Stably-dispersed and surface-functional bionanoparticles prepared by self-assembling amphipathic polymers of hydrophilic poly (y-glutamic acid) bearing hydrophobic amino acids. Chem Lett 33 398-399... [Pg.58]

Morillo M, Martinez de Ilarduya A, Munoz-Guerra S (2001) Comblike alkyl esters of biosynthetic poly(y-glutamic acid). 1. Synthesis and characterization. Macromolecules 34 7868-7875... [Pg.58]

Shimokuri T, Kaneko T, Serizawa T et al (2004) Preparation and thermosensitivity of naturally occurring polypeptide poly(y-glutamic acid) derivatives modified by alkyl groups. Macromol Biosci 4 407-411... [Pg.58]

Shih IL, Van YT (2001) The production of poly(y-glutamic acid) from microorganisms and its various application. Bioresource Technol 79 207-225... [Pg.59]

Bodnar M, Kjoniksen AL, Molnar RM et al (2008) Nanoparticles formed by complexation of poly-y-glutamic acid with lead ions. J Hazard Mater 153 1185-1192... [Pg.59]

Radu JEF, Novak L, Hartmann JF et al (2008) Structural and dynamical characterization of poly-y-glutamic acid-based cross-linked nanoparticles. Colloid Polym Sci 286 365-376... [Pg.59]

Kang HS, Park SH, Lee YG et al (2007) Polyelectrolyte complex hydrogel composed of chitosan and poly(y-glutamic acid) for biological application Preparation, physical properties, and cytocompatibility. J Appl Polym Sci 103 386-394... [Pg.60]

Lin YH, Chung CK, Chen CT et al (2005) Preparation of nanoparticles composed of chitosan/ poly-y-glutamic acid and evaluation of their permeability through Caco-2 cells. Biomacromolecules 6 1104-1112... [Pg.60]

Hajdu I, Bodnar M, Filipcsei G et al (2009) Nanoparticles prepared by self-assembly of chitosan and poly-y-glutamic acid. Colloid Polym Sci 286 343-350... [Pg.60]

Akagi T, Kaneko T, Kida T et al (2005) Preparation and characterization of biodegradable nanoparticles based on poly(y-glutamic acid) with L-phenylalanine as a protein carrier. J Control Release 108 226-236... [Pg.60]

Peng SF, Yang MJ, Su CJ et al (2009) Effects of incorporation of poly(y-glutamic acid) in chitosan/DNA complex nanoparticles on cellular uptake and transfection efficiency. Biomaterials 30 1797-1808... [Pg.62]

Hamasaki T, Uto TA et al (2010) Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(y-glutamic acid) nanoparticles. Clin Vaccine Immunol 17 748-756... [Pg.63]

Wang X, Uto T, Akagi T et al (2008) Poly(y-glutamic Acid) nanoparticles as an efficient antigen delivery and adjuvant system potential for an anti-AIDS vaccine. J Med Virol 80 11-19... [Pg.63]

Okamoto S, Yoshii H, Akagi T et al (2007) Influenza hemagglutinin vaccine with poly (y-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity. Vaccine 25 8270-8278... [Pg.63]

Okamoto S, Matsuura M, Akagi T et al (2009) Poly(y-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice. Vaccine 27 5896-5905... [Pg.63]

Okamoto S, Yoshii H, Ishikawa T et al (2008) Single dose of inactivated Japanese encephalitis vaccine with poly(y-glutamic acid) nanoparticles provides effective protection from Japanese encephalitis virus. Vaccine 26 589-594... [Pg.63]

Matsuo K, Yoshikawa T, Oda A et al (2007) Efficient generation of antigen-specific cellular immunity by vaccination with poly(y-glutamic acid) nanoparticles entrapping endoplasmic reticulum-targeted peptides. Biochem Biophys Res Commun 362 1069-1072... [Pg.63]

Yoshikawa T, Okada N, Oda A et al (2008) Nanoparticles built by self-assembly of am phiphilic poly(y-glutamic acid) can deliver antigens to antigen-presenting cells with high efficiency Anew tumor-vaccine carrier for eliciting effector T cells. Vaccine 26 1303-1313... [Pg.63]

Akagi T, Higashi M, Kaneko T et al (2005) In vitro enzymatic degradation of nanoparticles prepared from hydrophobically-modified poly (y-glutamic acid). Macromol Biosci 5 598-602... [Pg.63]

The addition of amphiphilic polymer in o/w or w/o/w emulsion systems is also useful to give surface functionality to MSs and NSs. Liang et al. reported preparation of NSs from poly(y-glutamic acid)-h-PLA, immobilizing galactose residues on the surface by an o/w emulsion method, and in vivo specific delivery of aniticancer... [Pg.81]

When azobenzenes are attached to polypeptides, photochromic reactions of azobenzenes can induce the change in helical properties of the polypeptides, which may be detected by CD spectrum as well as optical rotation. For 4-phenylazophen-ylamine-condensed poly(y-glutamic acid) A-9 containing up to 80 mol% of 4-phenylazophenylamide side chain, UV irradiation in organic solvents, such as... [Pg.251]

There are many kinds of natural biodegradable polymers. They are classified into three types according to their chemical structures, i.e., polysaccharides, polypeptides/proteins and polynucleotides/nucleic acids. Among them, polysaccharides, such as cellulose, chitin/chitosan, hyaluronic acid and starch, and proteins, such as silk, wool, poly( y-glutamic acid), and poly(e-lysin), are well known and particularly important industrial polymeric materials. [Pg.772]

Poly(y-glutamic acid), an analogue of poly (aspartic acid) with another methylene group in the side chain (12.35), is produced by Bacillus subtilis.188 (Notice that polyglutamic acid made by chemical synthesis involves the other carboxylic group.) Esterification improves the pro cessibility and the solubility in organic solvents. [Pg.377]

Lee, H.-Y, Jeong, Y.-L, and Choi, K.-C. (2011). Hair dye-incorporated poly-y-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation, Int.J. Nanomed., 6, 2879-2888. [Pg.551]

H. Kubota, Y. Nambu, T. Endo, Alkaline hydrolysis of poly (y-glutamic acid) produced by microorganism, J. Polym. Sci. A Polym. Chem. 34 (1996) 1347-1351. [Pg.64]

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