Amphipathic polymers

Matsusaki M, Hiwatari K, Higashi M et al (2004) Stably-dispersed and surface-functional bionanoparticles prepared by self-assembling amphipathic polymers of hydrophilic poly (y-glutamic acid) bearing hydrophobic amino acids. Chem Lett 33 398-399... 

Steric Stabilization. A third stabilization mechanism that is normally achieved by amphipathic polymers or by nonionic surfactants is steric stabilization. To be a candidate for steric stabilization, the polymers must consist of long segments, which are soluble in the liquid medium, interspersed by short segments, usually called anchors which are strongly adsorbed at the oil-water interface (Figure 17). 

Amphipathic polymers streptococci Serves as the NVS serotype 1 antigen. 

Pocanschi CL, Dahmane T, Gohon Y, Rappaport F, Apell HJ, Kleinschmidt JH, Popot JL (2006) Amphipathic polymers tools to fold integral membrane proteins to their active form. Biochemistry 45 13954-13961... 

The effectiveness of amphipathic polymer molecules in imparting steric stabilization can be understo< if a second identical particle is imagined to approach the one portrayed in Fig. 2.2. The stabilizing moieties must be mutually repulsive if the polymer is to impart stability. In these circumstances, the Brownian collision stresses the stabUizing molecules, which endeavour to escape from the stress zone. This escape can be effected either by desorption from the particle surface or by laterd movement over the particle surface... 

Woodle MC, Engbers CM, Zalipsky S. New amphipathic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes. Bioconjugate Chem 1994 5 493 96. 

Surface-Modified Enzymes. Enzymes acting in nearly anhydrous organic solvents always give rise to heterogeneous systems (Sect. 3.1). In order to turn them into homogeneous systems, which can be controlled more easily, proteins can be modified in order to make them soluble in lipophilic organic solvents. This can be readily achieved by covalent attachment of the amphipathic polymer polyethylene glycol (PEG) onto the surface of enzymes [460]. The pros and cons of PEG-modified enzymes are as follows [461, 462] ... 

Keywords Amphipathic polymers Bifunctionalized homopolymers Dual-func-timial polymers Poly(glycidyl methacrylate) Post-polymerization modification Sequential reactions siRNA delivery Thiol-epoxy reaction... 

Scheme 7 Chemical stractures of the amphipathic polymer family investigated for their siRNA delivering properties...

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