Poly degradation behavior

Deschamps AA, Grijpma DW, and Feijen J. Poly(ethylene oxide)/poly(butylenes terephthalate) segmented block copolymers The effect of copolymer composition on physical properties and degradation behavior. Polymer, 2001, 42, 9335-9345. 

Photophysical Processes and Photodegradation of Poly(ethylene terephthalate-co-2,6-naphtha1enedi carboxyl ate) Copolymers. We have recently reported the photophysical processes and the photo-degradative behavior of Doly(ethylene terephthalate-co-2,6-naphthalenedicarboxyl ate), PET-2,6-ND, copolymer yarns containing 0.5 - 4.0 mole percent 2,6-naphthalenedicarboxyl ate, 2,6-ND (1) and the parent naphthalenedicarboxyl ate monomer, Figure 3 and 4. 

With continuous development of systems for controlled drug release, new materials are being used whose influence on peptide stability must be carefully examined. Thus, the model hexapeptide Val-Tyr-Pro-Asn-Gly-Ala (Fig. 6.30) embedded in poly (vinyl alcohol) and poly(vinyl pyrrolidone) matrices had rates of deamidation that increased with increasing water content or water activity, and, hence, with decreasing glass transition temperature (Tg). However, the degradation behavior in the two polymers differed so that chemical reactivity could not be predicted from water content, water activity, or T% alone. Furthermore, the hexapeptide was less stable in such hydrated polymeric matrices than in aqueous buffer or lyophilized polymer-free powders [132],... 

Du LC, Meng YZ, Wang SJ, Tjong SC (2004) Synthesis and degradation behavior of poly (propylene carbonate) derived from carbon dioxide and propylene oxide. J Appl Polym Sci 92 1840-1846... 

Hiskins JN, Grayson JM (2009) Synthesis and degradation behavior of cyclic poly(E-caprolactone). Macromolecules 42 6406—6413... 

Abstract. This paper reviews the degradation behavior of aliphatic polyesters of current interest, including polylactide, polycaprolactone, poly(3-hydroxybutyrate) and their copolymers. Special focus is given to degradation products formed in different abiotic and biotic environments. The influence of processing and processing additives on the properties and degradation behavior is also briefly discussed. 

Proteins or poly(a-amino acids) feature the amide link common to the polyamides and may, in fact, be considered to be a-carbon substituted polyamide-2 variants. Thus, their potential thermal degradation behavior might be expected to be similar to that of the aliphatic polyamides defined earlier. 

Copolymers of DXO and d,l-LA were synthesized in different molar concentrations in their recent attempts [245]. In vitro hydrolysis studies on the copolymers showed degradation times up to 250 days. Microspheres intended for drug delivery were prepared from poly[TMC-co-CL], PAA and PLGA [245]. SEM studies showed that the microsphere morphology depends on the concentration at the time of preparation and on the choice of polymer. The drug release profiles showed dependence on the polymer degradation behavior and on the water penetration into the microsphere [245]. 

The MW of polymers of aliphatic disubstituted acetylenes such as 2-octyne remarkably reduces, when such polymers are irradiated with y-rays in airll7) (Fig. 10). In contrast, polymers of aromatic disubstituted acetylenes like 1-phenyl-1-propyne hardly degrade by y-rays irradiation in air. Thus the degradation behavior of substituted poly acetylenes is greatly dependent on the kind of substituent. The mechanism is essentially the same as that for thermal degradation. 

Yu, F. Zhuo, R. Synthesis, characterization, and degradation behaviors of end-group-functionalized poly(trimethylene carbonate)s. Polym. J. 2003, 35 (8), 671-676. 

Garkhal, K., Verma, S., Jonnalagadda, S., Kumar, N. Fast degradable poly(L-lactide-co- -caprolactone] microspheres fortissue engineering Synthesis, characterization, and degradation behavior. PartAPolvm.Chem.. 2007,45, 2755-2764. 

J. Yang, F. Wang, T. Tan, Degradation behavior of hydrogel based on crosslinked poly (aspartic acid), J. Appl. Polym. Sd. 117 (2010) 178-185. 

K.Y. Lee, K.H. Bouhadir, D.J. Mooney, Degradation behavior of covalently cross-linked poly (aldehyde guluronate) hydrogels. Macromolecules 33 (1) (2000) 97-101. 

G. Singh, N. Kaur, H. Bhunia, P.K. Bajpai, U.K. Mandal, Degradation behaviors of linear low-density polyethylene and poly(L-lactic acid) blends. J. Appl. Polym. Sci. 124, 1993-1998 (2012)... 

Ignatius, A.A., Augat, P. and Claes, L.E. (2001) Degradation behavior of composite pins made of tricalcium phosphate and poly(L,DL-lactide). Journal of Biomaterials Science, Polymer Edition, 12, 185-194. 

Miyazaki S, Takahashi K, Shiraki M, Saito T, Tezuka Y, Kasuya K (2000) Properties of a poly(3-hydroxybutyrate) depolymerase from Penicillium funiculosum. J Polym Environ 8 175-182 Mukai K, Yamada K, Doi Y (1992) Extracellular polyhydroxyalkanoate depolymerases and their inhibitor from Pseudomonas lemoignei. Int 1 Biol Macromol 14 235-239 MiiUer B, Jendrossek D (1993) Purification and properties of poly(3-hydroxyvaleric acid) depolymerase from Pseudomonas lemoignei. Appl Microbiol Biotechnol 38 487-492 Murase T, Iwata T, Doi T (2001a) Direct observation of enzymatic degradation behavior of poly[(R)-3-hydroxybutyrate] lamellar single crystals by atomic force microscopy. Macromolecules 34 5848-5853... 

Murase T, Iwata T, Doi Y (2001b) Atomic force microscopy investigation of poly[(R)-3-hydroxy-butyrate] lamellar single crystals relationship between molecular weight tuid enzymatic degradation behavior. Macromol Biosci 1 275-281... 

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