Poisoning suicides

The consequences of benzodiazepine use in the elderly may be severe. Benzodiazepines are common in drug poisoning suicides in the elderly (Carlsten et al. 2003). This is especially apparent for the hypnotics flunitrazepam and nitrazepam. Benzodiazepines are also associated with an increased risk of motor vehicle crashes in the elderly (Hebert et al. 2007). 

The main cases of poisoning have been as a result of its use in preparations for killing pests such as cockroaches and rats. In the first half of the twentieth century several hundred accidental poisonings, suicides, and homicides were due to the use of Zelio paste (containing thallium... 

During World War I. Haber was in charge of the German poison gas program. In April of 1915. the Germans used chlorine for the first time on the Western front, causing 5000 fatalities. Haber s wife. Clara, was aghast she pleaded with her husband to forsake poison gas. When he adamantly refused to do so. she committed suicide. 

Margit Szollosi-Janze. Fritz Haber 1868-1934 Eine Biographie. Munich Verlag C. H. Beck, 1998. This authoritative biography of Haber scrupulously sorts fact from fiction unfortunately there is no English translation of this 928-page book. Source for facial scar attempt to become reserve officer role of sanitariums and Habers stays in them Clara as chemist and professor s wife Haber s BASF contract Reform Movement Clara s despairing letter Prussian ideals Haber as Archimedes his responsibility for poison gas and wartime authoritarianism Clara and poison gas Sackur Haber leaves after Clara s suicide Haber s postwar depression, Nobel Prize, postwar gas research, and help for Weimar Republic April 1933 events to end and Zyklon B. 

Merlin Brubaker (source for vial of poison and suicide threat DVA and explosions) Crawford H. Greenewalt (source for Bolton s focus on 6-6, and Carothers calling Helen Sylvia ) Julian Hill (source for small Midwest colleges Du Pont s... 

No data are available on platelet NTE activity in exposed subjects, and little data on lymphocyte NTE activity. In one reported case of suicidal poisoning with chlorpyrifos, inhibition of lymphocyte NTE was correlated with the enzyme inhibition in peripheral nerves (Osterloh et al., 1983). In another case of attempted suicide with the same compound, inhibition of NTE in peripheral lymphocytes was associated with the development of delayed neuropathy (Lotti, 1986). However, the threshold of NTE inhibition required for delayed neuropathy remains undetermined (Lotti, 1987). Observations in occupationally exposed subjects are limited in number, and more research is needed to investigate the applicability of NTE as a biomarker of exposure to OP pesticides. 

In a poisoning incident in Pakistan, patients with convulsions (sampling time not specified) had measurable blood levels of endrin ranging from 0.0003 to 0.254 ppm (Rowley et al. 1987). Tissues of a suicide victim contained the following concentrations of endrin 11 days after ingestion of 12 g of endrin in a formulation product 0.07 mg/L in blood, 89.5 mg/kg in adipose tissue, 0.87 mg/kg in heart, 0.89 mg/kg in brain, 0.55 mg/kg in kidneys, and 1.32 mg/kg in liver (Runhaar et al. 1985). 

Musculoskeletal Effects. Muscular rigidity was observed in humans after acute cyanide poisoning (Grandas et al. 1989) and rhabdomyolysis, a clinical syndrome characterized by skeletal muscle injury, was observed in a man who ingested 0.57 mg CNVkg in a suicide attempt (Saincher et al. 1994). 

No studies were located in humans regarding the oral absorption of 1,2-dibromoethane. However, there is evidence to suggest that oral absorption occurs in humans. Death and poisoning resulting from suicide attempts (Olmstead 1960 Saraswat et al. 1986) and from consumption of contaminated fruits, grains, and drinking water (ERA 1983), indicate that absorption occurred. 

Those early metallurgists who were clever enough to learn how to transform crude ores to shiny metals were prohahly also observant enough to discover that some of the materials being worked with could harm them. Some of the earliest written accounts of humans on earth provide evidence that the ancient Greeks and Romans were well aware of the poisonous properties of certain plants and metals. The case of the poisoning of Socrates with hemlock is only the most famous of the early references to the deliberate use of certain plants for suicidal or homicidal purposes. 

One of the most carefully worked out dose-response relationships is that for carbon monoxide poisoning. Based on controlled studies of exposure in humans at low levels and on observations in humans who have suffered high level exposures because of their occupation or because of accidents or suicide attempts, the relationship between blood levels of carboxyhemoglobin (COHb) and toxicity is understood as follows ... 

No studies were located regarding death in humans after oral exposure to heptachlor or heptachlor epoxide. However, since heptachlor is a major component of the insecticide chlordane, chlordane poisoning can be considered when evaluating heptachlor toxicity data. In the case study of a woman who ingested 6 g of chlordane with suicidal intent and died 9.5 days following ingestion, no information was presented on the composition of the chlordane. Therefore, the amount of heptachlor exposure is unknown, and the effect of other components of chlordane cannot be ruled out (Derbes et al. 1955). 

Case reports describe a particular effect observed in an individual or a group of individuals in which an exposure to a substance has occurred, often accidentally or in suicidal attempts. Information can be obtained from published case reports or from poison information centers. 

A few deaths have been reported after poisoning by EPN, most resulting from suicidal ingestion, but at least one death has been associated with EPN spraying. It is moderately to highly toxic in animals, but less potent than parathion. ... 

Hundreds of deaths associated with parathion exposure have been reported. These deaths have resulted from accidental, suicidal, and homicidal poisonings. It has been the cause of most crop worker poisonings in the United States. Fatal human poisonings have resulted from ingestion, skin exposure, and inhalation (with varying degrees of skin exposure). 

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