Pleurodeles waltl

NEWT, Pleurodeles waltl Embryos and larvae exposed to visible light alone, ultraviolet radiation alone, BaP alone at 12.5-500 pg/L, or combinations Visible light alone, UV radiation alone, or BaP alone 27 had no toxic effects. Genotoxic effects were observed at 500 pg BaP/L plus visible light, or 25 pg BaP/L plus UV radiation... 

Chromosomal aberrations, B6C3Fi mice bone marrow cells in vivo Micronucleus formation, B6C3Fi mice bone marrow cells in vivo Micronucleus test, Pleurodeles waltl in vivo Binding (covalent) to DNA, RNA or protein, CrhCD rat liver... 

Micronucleus formation, newt larvae (Pleurodeles waltl) blood cells in vivo - 75 ppm 12 d Fernandez etal. (1993)... 

Mieronueleus assay in Pleurodeles waltl (newt) larvae red blood cells in vivo + 12.5 pg/mL 12 d L Haridon et al. (1993)... 

Mieronueleus test, Pleurodeles waltl erythroeytes in vivo (+) 0.125 Le Curieux et al. (1995)... 

Mieronueleus test, Pleurodeles waltl, larvae erythrocytes + 6 (water). layleteZa/. (1986)... 

Le Curieux F, Marzin D, Erb F. 1992. Genotoxic activity of three carcinogens in peripheral blood erythrocytes of the newt Pleurodeles waltl. Mutat Res 283 157-160. 

Pleurodeles waltl and Ambystoma mexicanum (axolotl), bred in many laboratories, were chosen because of the abundance of mucins which surround their eggs. The first analyses led to the isolation of Lewis and Lewis antigenic determinants, which are known to be related to human tumor-associated antigens. For these reasons, the jelly coats of amphibian eggs could represent a valuable model to examine 0-linked carbohydrate structures during evolution, associated with a possible function involving specific markers for the fertilization process. 

The mucin of Pleurodeles waltl (Fig. 1) appeared to be an abundant source of Le, Le and A Le> antigenic determinants, which can be prepared on a large scale, after removing Kdn by mild acidolysis. The mucin of Ambystoma maculatum (Fig. 3) contained essentially the determinant GalNAc( 31 )[Fuc(al-3)]GlcNAc, which has also... 

Becker CG, Becker T, Roth G. Distribution of NCAM-180 and polysialic acid in the developing tectum mesencephali of the frog Discoglossus pictus and the salamander Pleurodeles waltl. Cell Tissue Research 1993 272 289-301. 

Becker, T., Becker, C. G., Niemann, U., Naujoks, M. C., Gerardy, S. R., and Roth, G., 1993b, Amphibian-specific regulation of polysialic acid and the neural cell adhesion molecule in development and regeneration of the retinotectal system of the salamander Pleurodeles waltl, J. Comp. Neurol. 336 532-544. 

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