Lewis x antigen

SLE Systemic lupus erythematosus SLe Sialyl Lewis X antigen SLO Streptolysin-O SLPI Secretory leucocyte protease inhibitor... 

Synthesis of a Hexasaccharide by Formation of the GlcNf -3)Gat Glycoside Bond Intermediate in the Synthesis of Lewis X-Antigens (Le ) [30bI... 

Nyame, A.K., Pilcher, J.B., Tsang, V.C.W. and Cummings, R.D. (1997) Rodents infected with Schistosoma mansoni produce cytolytic IgG and IgM antibodies to the Lewis X antigen. Clycobiology 7, 207-21 5. 

Srivatsan, J., Smith, D.F. and Cummings, R.D. (1992b) The human blood fluke Schistosoma mansoni synthesizes glycoproteins containing the Lewis X antigen. Journal of Biological Chemistry 267, 20196-20203. 

Enzymatic glycosylation on SP was first reported by Schuster et al. (157) and since then has been used to perform multiple glycosylations. Two examples are reported in Fig. 2.28. The synthesis of oligosaccharides 2.94 and 2.95 related to the sialyl Lewis X antigen was carried out via glycosylations mediated by P-l,4-galactosyltransferase and a-2,3-sialyltransferase (171) and by p-l,4-galactosyltransferase, a-2,3-sialyl-transferase, and fucosyltransferase (172), respectively. The use of unprotected saccha-... 

In granulocytes, no branching of poly-Al-acetyllactosamines is observed, a 1-3-Fucosyltrans-ferase-catalyzed modification of the linear chains leads to the Lewis x antigen. If a2-3-sia-lyltransferase acts before fucosylation, sialyl Lewis x is formed. These carbohydrate stmc-tures are involved in a number of cell-cell interactions during the inflammatory response and... 

Stimulation of cultured endothelial cells with thrombin, histamine, or H202 results in a rapid (within minutes) translocation of P-selectin (CD62P) to the cell surface from secretory granules known as Weibel-Palade bodies. In contrast, induction of endothelial E-selectin (CD62E) expression is dependent upon de novo synthesis following stimulation with cytokines such as IL-1 a and TNF-a.57 58 P- and E-selectin are only transiently expressed on the cell surface, during which time they bind to the sialylated Lewis X antigens of neutrophils and monocytes.59-61 Both selectins are implicated in leucocyte extravasation associated with the acute inflammatory response.62-63... 

Ree HJ, Teplitz C, Khan A. The Lewis X antigen. A new pataffin section matket fot Reed-Stetnbetg cells. Cancer. 1991 67 1338-1346. 

Nanosecond Molecular Dynamics and NMR Study of Conformational Transitions in the Sialyl-Lewis X Antigen. 

Compound (15), an isomer of sialyl Lewis X antigen varying in the position of substitution of the sialic acid, has been synthesized. ... 

DeBose-Boyd RA, Nyame AK, Jasmer DP, Cummings RD (1998) The ruminant parasite Haemonchus contortus expresses an al,3-fucosyltransferase capable of synthesizing the Lewis x and sialyl Lewis x antigens. Glycoconj J 15 789-98. 

---