Plasma isoflavones

COWARD L, KIRK M, ALBIN N and BARNES s (1996) Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction ion monitoring-mass spectrometry. Clin Chim Acta. 247 (1-2) 121-42. 

Mean plasma isoflavone concentrations (after deconjugation) some 5 to 6h after consumption of soya-based foods have been reported as follows daidzein 0.5 to 3.1 p.M genistein 0.3 to 4.1 pM glycitein 0.20 to 0.85 Some data for the individual conjugates of... 

We found in several populations significant linear correlations of soy or isoflavone intake with urinary isoflavones [Franke et al., 1999 Jaceldo-Siegl et al., 2008]. This was confirmed by others who found these correlations with either urinary isoflavones [Atkinson et al., 2002 Slavin et al., 1998], plasma isoflavones [Frankenfeld et al., 2003 Heald et al., 2007 Wu et al., 2004], or both [Arai et al., 2000 Grace et al., 2004 Low et al., 2006 Ritchie et al., 2004 Yamamoto et al., 2001]. The correlations were highest (up to r = 0.6) for recent intake data (food diaries) and weaker (approximately r = 0.2) or disappeared for long-term intake measures (food frequency questionnaires). This is expected... 

Franke AA, Custer LJ, Hundahl SA. 2004b. Determinants for urinary and plasma isoflavones in humans after soy intake. Nutr Cancer 50 141-154. 

Frankenfeld CL, Patterson RE, Horner NK, Neuhouser ML, Skor HE, Kalhorn TF, Howald WN, Lampe JW. 2003. Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women. Am J Clin Nutr 77 674-680. 

Wu AH, Yu MC, Tseng CC, Twaddle NC, Doerge DR. 2004. Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles county. Carcinogenesis 25 77-81. 

Regarding the metabolic components of isoflavones from soy-based infant formula, it is thought that the plasma isoflavone concentrations for 4-month-... 

SF are not widely consmned in Western diets and therefore dietary SI intakes range from less than 1 to several mg/day (Mulligan et al. 2007), with plasma isoflavone concentrations sta5dng in the lower nanomolar range. Primary sources are traditional soy-based foods and hidden... 

Gooderham, M.H., Adlercreutz, H., Ojala, S.T., Wahala, K., and Holub, B.J. 1996. A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. JNutr 126, 2000-2006. 

Kurahashi, N., Iwasaki, M., Inoue, M., Sasazuki, S., and Tsugane, S. 2008. Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study the Japan Public Health... 

Nagata et al., 2002 Japanese postmenopause n= 87 The estimated average intake of isoflavones was 32 mg/d and plasma concentrations around 0.6 gM Soy product and isoflavone intake and serum isoflavones were not significantly correlated with BMD at the calcaneous site. 

HSU 0 s, SHEN w w, HSUEH, Y M and YEH s L (2001) Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzye activities and bone density. JReprod Med 46, 221-6. 

RICHELLE M, PRIDMORE-MERTEN S, BODENSTAB S, ENSLEN M, OFFORD E A (2002) Hydrolysis of isoflavone glycosides to aglycones by (3-glycosidase does not alter plasma and urine isoflavone pharmacokinetics. J Nutr 132, 2587-92. 

WATANABE S, YAMAGUCHI M, SOBUE T, TAKAHASHI T, MIURA T, ARAI Y, MAZUR W, WAHALA K, and ADLERCREUTZ H (1998) Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60g baked soybean powder (Kinako). J Nutr 128, 1710-15. 

Such evidence indicates that it might be unnecessary to reach the same intake of soy products as Japanese or other Asian populations to reach the same plasma levels of isoflavones. The rationale for such a difference could be a different bioavailability of the ingested isoflavones. Indeed, in most Asians a deficiency of an intestinal lactase, responsible for P-glucosides hydrolysis, might explain the lower isoflavones concentrations in the blood of the Japanese (Day et ai, 2000). 

CROUSE J R 3" , MORGAN T, TERRY J G, ELLIS J, viTOLiNS M and BURKE G L (1999) A randomised trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med. 159 (17) 2070-76. 

GARDNER c D, NEWELL K A, CHERiN R and HASKELL w L (2001) The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. dm J Clin Nutr. 73 (4) 728-35. 

KING R A and BURSILL D B (1998) Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr. 67 (5) 867-72. 

MERZ-DEMLOW B E, DUNCAN A M, WANGEN K E, XU X, CARR T P, PHIPPS W R and KURZER M S (2000) Soy isoflavones improve plasma lipids innormocholesterolemic, premenopausal women. Am J Clin Nutr. 71 (6) 1462-9. 

Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vase Biol. 17 (12) 3392-8. 

On patients with cancer, the effects of green tea catechins, soy isoflavones and quercetin as chemoprotective/chemotherapeutic agents have also been studied. Although results have not been entirely satisfactory, a partial response has been achieved in some trials. For example, small decreases in plasma concentration of prostate-specific antigen were observed in prostate cancer patients who consumed soy isoflavones. Nevertheless, results in individuals with premalignant disease who consumed green tea polyphenols support their advancement into phase III clinical intervention trials aimed at the prevention of PIN, leukoplakia, or premalignant cervical disease (Thomasset and others 2006). 

Crouse, J.R., Morgan, T., Terry, J.G., Ellis, J., Vitolins, M. and Burke, G.L. (1999). A randomized trial comparing the effect of caseine with that of soy protein containing varying amount of isoflavones on plasma concentration of lipids and lipoproteins, Arch. Intern. Med., 159, 2070-2076. 

Greaves, K.A., Parks, J.S., Williams, J.K. and Wagner, J.D. (1999). Intact dietary soy protein, but not adding an isoflavone-rich soy extract to casein, improves plasma lipids in ovariectomized cunomologus monkeys, J. Nutr., 129, 1585-1592. 

Nestel, P.J., Pomeroy, S., Kay, S., Komesaroff, P., Behrsing, J., Cameron, J.D. and West, L. (1999). Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women, J. Clin. Endocrinol. Metab., 84, 895-898. 

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