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Intestinal Lactase

Such evidence indicates that it might be unnecessary to reach the same intake of soy products as Japanese or other Asian populations to reach the same plasma levels of isoflavones. The rationale for such a difference could be a different bioavailability of the ingested isoflavones. Indeed, in most Asians a deficiency of an intestinal lactase, responsible for P-glucosides hydrolysis, might explain the lower isoflavones concentrations in the blood of the Japanese (Day et ai, 2000). [Pg.209]

Neomycin - Orally administered neomycin increases fecal bile acid excretion and reduces intestinal lactase activity. [Pg.1653]

Small-intestine lactase (GH 1), the absence of which is associated with lactose intolerance in a large proportion of the adult population, was probed with monodeoxy as well as selected mono-O-methyl derivatives in the galactose moiety of methyl lactosides.112 This enzyme required hydroxyl groups at C-2 and also C-3, while neither the presence of a 4-OH group nor a specific configuration at C-4 was prerequisites for successful hydrolysis. A 6 -deoxy lactoside was readily hydrolyzed, but the absence of 6-OH in the gluco moiety caused it to be a poor substrate. [Pg.199]

A. Rivera-Sagredo, F. J. Canada, O. Nieto, J. Jimenez-Barbero, and M. Martin-Lomas, Substrate specificity of small-intestinal lactase Assessment of the role of the substrate hydroxyl groups, Eur. J. Biochem., 209 (1992) 415 122. [Pg.281]

Lactose intolerance can be readily managed by ensuring that the amount of lactose ingested is restricted to the amount the individual can tolerate, which is related to the individual s level of residual intestinal lactase activity. Lactose maldigesters can determine their individual threshold for the occurrence of lactose intoler-... [Pg.275]

Buller, H. A., Montgomery R, K Sasak, W. V and Grand, R. J. (1987). Biosynthesis, glyco-svlation, and intracellular transport of intestinal lactase-phlorizin hydrolase in rat. /. Biiji Cftcrrr. 262,17206-17211. [Pg.131]

The enzyme lactase catalyzes the hydrolysis of lactose in the lumen of the gut. Generally, intestinal lactase activity occurs at a maximal level from birth through early childhood. Then activity declines to a residual level of 5 10% by the age of. 3 or later in most populations of the world. In persons of European descent, lactase activity can remain at a high level throughout adulthood. Low levels of lactase... [Pg.136]

Intestinal lactase deficiency is a common condition in which lactose cannot be digested and is oxidized by bacteria in the gut, producing gas, bloating, and watery diarrhea. [Pg.173]

Lactose is sometimes detected in the urine of women during lactation and occasionally toward the end of pregnancy. Patients with lactase deficiency, a common disorder caused by a congenital or acquired deficiency of intestinal lactase, exhibit abdominal pain, diarrhea, and lactose in the urine. [Pg.889]

Flatz G. The genetic polymorphism of intestinal lactase activity in adult humans. In Scriver CR,... [Pg.1885]

Jost, B., Vilotte, J.-L., Duluc, L, Rodeau, J.-L., and Freund, J.-N. (1999). Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland. Nat. Biotechnol. 17,160-164. [Pg.195]

Lactase (intestinal) (EC 3.2.1.23). Lactase is present in infancy when it is required for digestion of lactose in the mother s milk. The enzyme then decreases markedly with age, so that abdominal pain and diarrhea result from drinking milk, due to failure to hydrolyse lactose in the intestinal mucosa and lactose malabsorption. Condition prevalent throughout the world, and hereditary persistence of high intestinal lactase activity prevails only on Northern European populations (and those derived from them) and certain Arab and Hamitic races. [Pg.317]

Exp. teratogen. Gastrointestinal effects if intestinal lactase activity is diminished. Mixtures with strong oxidants are explosive. May cause allergy in sensitive patients. OD9625000 Phenylosazone Lactosazone [4746-17-2]... [Pg.677]

Food contains one polysaccharide (starch) and three disaccharides (maltose, sucrose, and lactose). Salivary and pancreatic amylase digests starch to yield maltose and sucrose, and lactose to yield maltose and sucrose. Sucrose, maltose, and lactose are split by invertase, maltase, and lactase, respectively. The products of the disaccharidase reactions are fructose, glucose, and galactose. Whenever amylase or one of the disacchari-dases is absent from the intestinal content, the undigested sugars pass in the lower part of the intestinal tract and are fermented by the bacterial flora. As a result, lactic acid and volatile acids are formed and stimulate peristalsis and fluid secretion by the intestinal mucosa. Liquid foaming acid and foul-smelling feces are emitted. Amylase may be absent in pancreatic disease. Inborn errors characterized by the absence of intestinal lactase, maltase, and invertase have been described. [Pg.318]

Relatively commonly, people lose intestinal lactase in late adolescence or early... [Pg.113]

Reduction to lactate, as occurs in human muscle. This is the pathway in lactic acid bacteria, which are responsible for the fermentation of lactose in milk to form yoghurt and cheese, and also for the gastrointestinal discomfort after consumption of lactose in people who lack intestinal lactase (section 4.2.2.2). [Pg.139]


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See also in sourсe #XX -- [ Pg.262 ]




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