Isoflavones daidzein

RUPP H, ZOLLER o, ziMMERELi B (2000) Bestimmung der isoflavone daidzein imd genistein in sohaltigen produkten. Mitt Lebsesm Hyg. 91 199-223. 

KING R A and BURSILL D B (1998) Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr. 67 (5) 867-72. 

Gut microflora metabolites may also be important. As discussed above, the mammalian lignan aglycones, enterodiol and enterolactone, are estrogenic, and equol is more estrogenic than its dietary precursor, the isoflavone daidzein. ... 

FIGURE 8.6 Structure of the phytoalexin isoflavonoid pterocarpans, maackianin, and pisatin from garden pea, and the isoflavones daidzein and genistein from soybean. 

Atkinson C, Frankenfeld CL, Lampe JW. 2005. Gut bacterial metabolism of the soy isoflavone daidzein Exploring the relevance to human health. Exp Biol Med (May-wood) 230 155-170. 

Heinonen SM, Hoikkala A, Wahala K, Adlercreutz H. 2003. Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects. Identification of new metabolites having an intact isoflavonoid skeleton. J Steroid Biochem Mol Biol 87 285-299. 

Kulling SE, Honig DM, Metzler M. 2001. Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo. J Agric Food Chem 49 3024-3033. 

Isoflavones Daidzein Genistein Glycitein Soy flour, soybeans boiled, tofu, soy milk... 

Figure 4.1 Chemical structures of the principal classes of polyphenols. The examples shown are of polyphenols with hydroxyl groups in the 7- and 4"-positions. Anthocyanins may also be found in oligomeric forms. The coumestane is coumestrol, The isoflavone (daidzein) differs from the flavonoid h the substitution of the phenolic group. For the flavonoid it is in the 2-position, whereas it is in the 3-position in the isoflavone.

Structural similarity of the isoflavones to estrogen has been responsible for claims that they are natural alternatives to hormone replacement therapy (HRT). Soy isoflavones are not usually present in humans, unless caused by acute or chronic administration of soy products in the diet. If not in the diet, supplementation is required. One synthetic isoflavone, ipriflavone, has been shown to increase bone mass in postmenopausal women. The soy isoflavone daidzein makes up 10%o of the metabolites of ipriflavone, and it appears to be one of the metabolites that inhibit osteoclast activity in vitro. A number of studies have been reported on the effects of soy protein and genistein on bone density in rats, and it appears that it is the isoflavones that are responsible for the beneficial effects. Positive data from studies with cultured bone cells support a... 

All isoflavones [daidzein (27), genistein (28)] and isoflavanones (17, 86-93) did not stimulate nitric oxide production by mouse macrophage-like Raw 264.7 cells, but almost completely inhibited NO production by the lipopolysaccharide (LPS)-activated Raw 264.7 cells. ESR spectroscopy showed that secundifloran (88) and secundiflorol D (90), which showed the most inhibitory effect for NO production, efficiently scavenged the superoxide anion and NO radicals. From these results, it is suggested that the inhibition of macrophage NO production by these isoflavanones might, at least in part, be explained by their radical scavenging or reduction activity (Fig. 17) (Tables 3, 4) [16]. 

Securinega suffructicosa Securinine Sesamum indicum Silybium marianum Silymarin Taxifolin Sophora flavescens Sphocar dipine Soybean isoflavones Daidzein Daidzin Genistein Genistin Glycitein Glyzitin... 

So far, there are two best documented examples of specificity in chemotaxis and subsequent differentiation of oomycete zoospores by host plant signals. The first one is the attraction, encystment and germination of A. cochlioides zoospores to a rare flavone, cochliophilin A (3), and the other one is Ph. sojae zoospores to isoflavones daidzein (4) and genistein (5)... 

Figure 38.1 Formulas of flavone, Isoflavone, and major soy Isoflavones daidzein and genistein.

Actual levels of thyroid hormones and major antithyroid autoantibodies, along with free isoflavones daidzein... 

Figure 2 Chemical structures of selected plant polyphenols. Structures include a flavonol (quercetin), isoflavone (daidzein), cinnamic acid (chlorogenic acid), flavan-3-ol (catechin), a lignan microbial metabolite (enterodiol), and a stilbene (resveratrol).

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