Photodynamic therapy photosensitizers

Keywords Photodynamic therapy Photosensitizer Photochemistry Reactive oxygen species Cancer Microorganism Infection... 

Sessler, J.L. et al. (1997) Biomedical applications of lanthanide(III) texaphyrins. Lutetium(III) texaphyrins as potential photodynamic therapy photosensitizers, J. Alloys Compd. 249, 146-152. 

Allison RD, Sibata CH (2010) Oncologic photodynamic therapy photosensitizers a clinical review. Photodiagn Photodyn Thta- 7 61-75... 

Natural Sensitizing Dyes and Photodynamic Therapy. The chlorophylls are, of course, among the natural sensitizers for photosynthesis. Considerable iaterest exists ia chlorophyll and related pigments as photosensitizers ia biology and medicine (75), isomeric retinal chromophores as visual pigments (76,77), and the use of synthetic photosensitizers ia neurobiology (9), hematology (78), and photodynamic therapy (79). 

Porphyrin-based photosensitizers for use in photodynamic therapy 98T4151. 

Wood, S.,et ah, Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofihns, J. Antimicrob. Chemother., 57, 680, 2006. Hurlstone, D.P., et ah. Indigo carmine-assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis a prospective evaluation. Endoscopy, 37,1186, 2005. 

Photodynamic therapy uses non-thermal red light to activate verteporfin, which produces reactive oxygen species that locally damage the neovascular endothelium.24 Verteporfin treatment reduces the risk of loss of visual acuity and legal blindness over 1 to 2 years. Long-term results are not yet available. Severe photosensitivity for 3 to 5 days after the procedure is common and some patients experience a severe loss of vision. Eventually, most patients have some visual recovery. This procedure requires multiple treatments over time.22... 

Photodynamic therapy is based on a phenomenon known as photodynamic action, or the photodynamic effect, which are terms used to describe the damage to living tissue caused by certain photosensitizers in the presence of visible light and oxygen. Again, there is an extensive historical record, which has been reviewed several times during the 1990s.4,9-15... 

J., Dougherty, T.J. and Prasad, P.N. (2003) Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs A novel drug-carrier system for photodynamic therapy. Journal of the American Chemical Society, 125, 7860-7865. 

Fig. 16 (a) Chemical structure of HA/photosensitizer conjugate conjugates and (b) strategy for photodynamic therapy. Reprinted from [260] with permission... 

R. K. Pandey and G. Zheng, Porphyrins as Photosensitizers in Photodynamic Therapy, Academic Press, San Diego, 2000. 

Detty MR, Gibson SL, Wagner SJ (2004) Current clinical and preclinical photosensitizers for use in photodynamic therapy. J Med Chem 47 3897-3915. 

Szeimies RM, Karrer S, Abels C, Steinbach P, Fickweiler S, Messmann H, Baumler W, Landthaler M (1996) 9-Acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene (ATMPn), a novel photosensitizer for photodynamic therapy uptake kinetics and intracellular localization. J Photochem Photobiol B 34 67-72. 

Presently photodynamic therapy (PDT) is considered as a perspective way for therapy of different diseases, including cancer. PDT is a method based on the local light-induced activation of photosensitizers able to accumulate selectively in energy-deficient cells (malignant or dysplastic ones) not influencing the remaining normal cells of the body (Pass, 1993). Upon the action of irradiation of certain wavelength characteristic for individual photosensitizer, photochemical reaction occurs... 

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