Intraepithelial neoplasia

Wood, S.,et ah, Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofihns, J. Antimicrob. Chemother., 57, 680, 2006. Hurlstone, D.P., et ah. Indigo carmine-assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis a prospective evaluation. Endoscopy, 37,1186, 2005. 

VanEenwyk J, Davis FG and Bowen PE. 1991. Dietary and serum carotenoids and cervical intraepithelial neoplasia. Int J Cancer 48 34-38. 

Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G and Corti A. 2006. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia a preliminary report from a one-year proof-of-principle study. Cancer Res 66(2) 1234—1240. 

Cervical intraepithelial neoplasia or cervical cancer Pelvic inflammatory disease... 

The presence of human papilloma virus (HPV) is associated with female genital tract diseases such as condyloma, Bowenoid papulosis, and cervical, vaginal, and vulvar intraepithelial neoplasia and carcinoma. A general concern is the association of HPV with cervical cancer (Gl). The HPV consists of an icosahedral viral particle (virion) containing 8000 base pairs, a circular, double-stranded piece of DNA surrounded by a protein capsid. Viral replication takes place within the nuclei of infected squamous epithelial cells (H5). Following infection of epithelial cells, the viral DNA penetrates throughout the entire thickness of the epithelium, but intact viruses are found only in the upper layers of tissue. 

Pech O, Gossner L, May A, Rabenstein T, Vieth M, Stolte M, Berres M, Ell C (2005) Long-term results of photodynamic therapy with 5-aminolevulinic acid for superficial Barrett s cancer and high-grade intraepithelial neoplasia. Gastrointestinal Endoscopy 62 24-30. 

GardasU Four placebo-controUed, double-blind, randomized Phase II and Phase III trials were conducted to evaluate the efficacy. Cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS), vulvar intraepithelial neoplasia (VIN), and genital warts were used as the surrogate markers. 

Gram IT, Macaluso M, Stalsberg H. Oral contraceptive use and the incidence of cervical intraepithelial neoplasia. Am J Obstet Gynecol 1992 167(l) 40-4. 

Prostatic intraepithelial neoplasia (PIN) 24 Increased in erythrocyte GSH levels Inhibits NF-kB, COX-2, and pSTAT3... 

The grade of vulvar intraepithelial neoplasia (VIN) can be scored by subclassifying it on the basis of the extent of cellular changes into three types (Van Beurden et al., 1999) ... 

Vulvar intraepithelial neoplasia show a spectrum of pathological alterations, including nuclear pleomorphism, hyperchromasia, altered epithelial maturation, cellular aggregation, loss of normal keratinocyte polarity, and atypical mitotic features (Wilkinson, 1992). 

Prostate Cancer 41,42, 45,44, 46,411 Progressive loss of annexins with increased histological stage. (Smitherman et al., 2004) Lehnigk et al., 2005) Annexin 1 expression reduced in prostatic adenocarcinoma and high-grade prostatic intraepithelial neoplasia (Kang et al., 2002 Patton et al., 2005) (Xin et al., 2003)... 

Kang, J.S., Calvo, B.F., Maygarden, S.J,. Caskey, L.S., Mohler, J.L., and D.K. Ornstein, 2002, Dysreg-ulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Clin Cancer Res. 8(1) 117-23. 

Patton, K.T., Chen, H.M., Joseph, L., and X.J. Yang, 2005, Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia. Histopathology. 47(6) 597-601. 

C34. Cope, G., Thorpe, G., Holder, R., Luesley, D., and Jordan, J., Serum and tissue antioxidant capacity in cervical intraepithelial neoplasia investigated using an enhanced chemiluminescent reaction. Am. Clin. Biochem. 36, 86-93 (1999). 

Bratthauer GL Combined E-cadherin and high molecular weight cytokeratin immunoprofde differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias. Hum. Pathol. 2002 33 620-627... 

Muderspach, L., Wilczynski, S., Roman, L., et al. (2000) A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin. Cancer Res. 6, 3406-3416. 

Imiquimod Treatment of high-grade vaginal intraepithelial neoplasia Cream Results suggest it can be an alternative conservative therapy 334... 

Trichloroacetic acid Treatment of low-grade vaginal intraepithelial neoplasia Solution Proved to be effective as well as inexpensive and easy to perform 341... 

Diakomanolis, E., Haidopoulos, D., and Stefanidis, K. (2002), Treatment of high-grade vaginal intraepithelial neoplasia with imiquimod cream, N. Engl. J. Med., 347, 374 (Letter). 

Lin, H., Huang, E. Y., Chang, H. Y., and ChangChien, C. C. (2005), Therapeutic effect of topical applications of trichloroacetic acid for vaginal intraepithelial neoplasia after hysterectomy, Jpn. J. Clin. Oncol, 35, 651-654. 

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