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Photodynamic therapy excited photosensitizer with

In addition, two-photon excitation can be another effective way to achieve NIR-triggered PDT/PTT synergistic therapy. For example, Li and coworkers also prepared hypocrellin-loaded AuNCs for two-photon PDT/PTT of cancer. The AuNCs were optimized to have efficient NIR absorption and further coated with lipids containing hydrophobic photosensitizer hypocrellin B (HB). The photodynamic effect of the photosensitizer was quenched in the Au nanostructure, thereby reducing side effects of the photosensitizer in unintended locations. For in vitro experiments, cancer cells were treated with the nanocomplex and irradiated with a 790 nm pulsed NIR laser. The photosensitizer HB was released from the AuNCs in the intracellular region, which induced dramatic phototoxicity due to the synergistic effect of PDT and PTT under two-photon irradiation. [Pg.357]


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