Phosphoric acid monohydrate

Adenosine-5 -phosphoric acid monohydrate [18422-05-4] M 365.2, m 196-200°(dec), [a]s4g -56° (c 2, 2% NaOH). Crystd from H20 by addition of acetone. Purified by chromatography on Dowex 1 (in formate form), eluting with 0.25M formic acid. It was then adsorbed onto charcoal (which had been boiled for 15min with M HC1, washed free of chloride and dried at 100°), and recovered by stirring three times with isoamyl alcohol/H20 (1 9 v/v). The aqueous layer from the combined extracts was evaporated to dryness under reduced pressure, and the product was crystallised twice from hot H20. [Morrison and Doherty BJ 79 433 7967], See entry in Chapter 5. 

Chemistry and Properties. TSP is essentially impure monocalcium phosphate monohydrate, Ca(H2P0 2 20, made by acidulating phosphate rock with phosphoric acid according to... 

Both monocalcium phosphate and dicalcium phosphate dissolve incongmently in water, disproportionating to more basic calcium phosphate and phosphoric acid. The extent of these reactions varies with the temperature and the amount of water. If water is added gradually to anhydrous monocalcium phosphate, equiUbrium conditions first correspond to a mixture of the anhydrous salt and its monohydrate. After conversion to the monohydrate, further reaction affords dicalcium phosphate plus free phosphoric acid. Dicalcium phosphate decomposes in aqueous solution to the more basic hydroxyapatite and phosphoric acid via intermediate octacalcium phosphate. The compHcated stepwise conversion of the acidic mono- and dicalcium phosphates to hydroxyapatite is summarized in equations 6—9. The kinetics are quite complex. 

Method A. A slurry of 3.15 g d-lysergic acid monohydrate (monohydrate means dry) and 7.3 g of diethylamine (or 0.1 mole of similar amine) in 150 ml of pure chloroform is heated to reflux. After the lysergic acid is dissolved (a few min) cool the mixture down to where reflux has stopped by removing the heat. Before the mixture cools any further 2 ml of phosphorous oxychloride is added at such a rate as to give reflux (about 2 min). After addition, reflux for 4-5 min further until an amber-colored solution results. Cool to room temp and wash the mixture with 200 ml of 1 M ammonium hydroxide. The chloroform solution was dried with MgSC>4 (this would have to be after separation), filtered, and concentrated by evaporation in vacuo under a temp of 38° (at no time let the temp go over 40°). The last traces of solvent are removed at 2-5 mm. Dissolve the residue in a minimum amount of methanol and acidify with freshly prepared solution of 20% maleic acid in methanol (not aqueous) to precipitate the LSD in its maleate form. Filter the fluffy white needles, wash with cold methanol and air dry to get 2.2 g of LSD that requires no further purification. 

O-phosphoric acid and/ or sodium hydroxide may be used for pH adjustment dihydrate 0.45mg/mL sodium dihydrogen phosphate monohydrate 0.1 mg/mL methionine 0.1 mg/mL Poloxamer 188 ... 

To a 12 L 3-neck round bottom flask with stir bar was added 2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoic acid methyl ester (126 g, 0.588 mol), water (1.3 L), and THF (3.9 L). The solution was cooled to 0°C in an ice-water bath and lithium hydroxide monohydrate (74 g, 1.76 mol) was added in one portion with rapid stirring. The solution was allowed to stir at 0°C for 14 hours. It was then acidified to pH 11 by slow addition of 50% aq. phosphoric acid and the THF was removed in vacuo. The aqueous phase was washed with isopropyl acetate (2 L) and was subsequently acidified to pH by slow addition of 35% aq. HCI. The aqueous layer was then extracted with ethyl acetate. The combined organic layers were concentrated to give the desired product (105 g) as a white solid. The compound was then purified by... 

The major use of phosphate is to supply phosphorous, one of the three essential plant foods, nitrogen, phosphorus, and potassium. Phosphate rock extraction from its ore, and its subsequent conversion into fertilizer materials and industrial chemicals, is a relatively mature art. Single superphosphate, a mixture of monocalcium monohydrate and gypsum formed by the reaction of sulfuric acid with phosphate rock, has been used as a fertilizer since the mid-1800s. Phosphoric acid, derived by the treatment of phosphate rock with sulfuric acid so as to produce gypsum in a separable form, was manufactured in many locations by batch and countercurrent decantation methods in the 1920s. 

Catalyst, alumina, 34, 79, 35, 73 ammonium acetate, 31, 25, 27 boron tnfluonde etherate, 38, 26 copper chromite, 31, 32, 36, 12 cupric acetate monohydrate, 38, 14 cuprous oxide silver oxide, 36, 36, 37 ferric nitrate, hydrated, 31, 53 phosphoric acid, 38, 25 piperidine, 31, 35 piperidine acetate, 31, 57 Raney nickel, 36, 21, 38, 22 sulfuric acid, 34, 26 Catechol, 33, 74 Cetylmalonic acid, 34, 16 Cetylmalonic ester, 34,13 Chlorination, by sulfuryl chloride, 33, 45, 37, 8... 

Rubidium phosphates.—The three phosphates are prepared by the interaction of phosphoric acid and rubidium hydroxide or carbonate in appropriate proportions.13 The primary phosphate, RbH2P04, is acidic in aqueous solution the other two are alkaline. When heated at 244° C. the primary phosphate loses water, yielding the acid pyrophosphate, RbaH2P207.14 The secondary phosphite forms a monohydrate,... 

CYCLOPHOSPHAMIDUM CYCLOPHOSPHAN CYCLOPHOSPHANE CYCLOPHOSPHANUM CYTO-PHOSPHAN CYTOXAN 2-pi(2-CHLOROETHYL)-AMINO)-l-OXA-3-AZA-2-PHOSPHACYCLOHEXANE-2-OXIDE MONOHYDRATE N,N-DI(2-CHLOROETHYL)-AMINO-N,0-PROPYLENE PHOSPHORIC ACID ESTER DIAMIDE MONOHYDRATE ENDOXANA ENDOX-. N-ASTA ENDOXAN MONOHYDRATE ENDOXAN R ENDUXAN GENOXAL MITOXAN NSC-26271 PROCYTOX SEMDOXAN SENDOXAN SENDUXAN... 

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