Codeine phosphate

It is known that not all reactions proceed in the same manner on all adsorbent layers because the material in the layer may promote or retard the reaction. Thus, Ganshirt [209] was able to show that caffeine and codeine phosphate could be detected on aluminium oxide by chlorination and treatment with benzidine, but that there was no reaction with the same reagent on silica gel. Again the detection of amino acids and peptides by ninhydrin is more sensitive on pure cellulose than it is on layers containing fluorescence indicators [210]. The NBP reagent (. v.) cannot be employed on Nano-Sil-Ci8-100-UV2S4 plates because the whole of the plate background becomes colored. 

Promethazaine HCl/w Codeine Cough Syrup—codeine phosphate, promethazine HC1 Quad Tann Tablets—carbetapentane tannate, chlorpheniramine tannate, phenylephrine tannate, ephedrine tannate... 

Tricodeine Cough Cold Liquid—codeine phosphate, pyrilamine maleate... 

Muskel Trancopal cum codeino (Winthrop)-comb. with paracetamol and codeine phosphate wfm Alinam (Lucien) wfm... 

Opioids. Reactions to morphine, codeine phosphate, meperidine, fentanyl and its derivatives are uncommon. Because of their direct histamine-releasing properties, especially regarding morphine and codeine, distinction between anaphylaxis and non-immune-mediated histamine release is not always easy. Only 12 cases were recorded in the last 2 years epidemiologic survey in France, 9 of them being related to morphine administration [9]. 

A formula for a cough syrup contains 1/8 gr of codeine phosphate per teaspoonful. How many grams of codeine phosphate should be used in preparing two pints of the cough syrup ... 

Codeine phosphate was duly extracted into CS2 and quantitatively determined by measuring its absorption at 942 cm1. 

Stubberud Persson, K., and Astrom, O. (1998). Separation of ibuprofen, codeine phosphate, their... 

In reference 68, a different approach was used to verify the robustness of a CE separation of ibuprofen, codeine phosphate, degradation products, and impurities in a drug product (tablet). Small variations around the optimal conditions obtained during method optimization were introduced and the results were predicted from the response model. The variations in the factor levels during the robustness evaluation were smaller than those evaluated during method optimization. Since both migration times and resolutions were acceptably predicted, the method was considered robust with respect to the small changes. The examined factors... 

Persson Stubberud, K., and Astrom, O. (1998). Separation of ibuprofen, codeine phosphate, their degradation products and impurities by capillary electrophoresis I. Method development and optimization with fractional factorial design. ]. Chromatogr. A 798, 307—314. 

An MEKC method for the determination of ibuprofen, codeine phosphate hemihydrate, their nine potential degradation products, and impurities in a commercial tablet formulation was developed, optimized, and fully validated according to ICH guidelines and submitted to the regulatory authorities. The optimized system containing ACN as organic modifier allowed baseline separation of ibuprofen, codeine, and nine related substances within 12 min. 

Carisoprodol/ASA/Codeine Phosphate Soma compound w/ Codeine 325/200/16 mg tablets... 

Opiates can effect serum levels of enzymes and other substances whose homeostatic control depends on clearance through the liver (F8, G12, M15, N4, S19). In one reported case, the aspartate aminotransferase was within normal limits before the administration of codeine, but within 2 hours after the drug, the enzyme activity had risen to two times the normal value by 8 hours to eight times the normal activity, and within 24 hours it had returned to normal (F8). Increases in transaminase to levels 5-85 times the control value have been reported in 6 of 16 patients with disease of the biliary tree following the administration of codeine phosphate (2 grains) (B7, F8). Gross has shown that morphine, codeine, or mepheridine administration produce elevations of serum amylase or lipase (G12). These elevations have been attributed to constriction of the sphincter of Oddi and increased intraductal pressure on the pancreatic duct (G12, N4). 

Codeine phosphate is still used for diarrhea predominantly based on hypermotility but the longer-acting loperamide is more convenient and has less central nervous system effects. Codeine has an exceptionally low affinity for opioid receptors and its effects are due to the fact that it is converted for approximately 10% to morphine. The active metabolite of morphine, morphine-6-glucuronide, may also accumulate during repeated administration of codeine to patients with impaired renal function. 

Stated content/tablet = aspirin 250 mg, paracetamol 250 mg, codeine phosphate... 

Weight of tablet powder taken for analysis = 0.1228 g Weight of t-butanol internal standard added = 8.0 mg Area of internal standard peak = 7.2 Area of aspirin CH3 peak = 5.65 Area of paracetamol CH3 peak = 6.73 Codeine phosphate CH3 peak = 0.115 MW t-butanol = 74.1 MW aspirin = 180.2 MW paracetamol = 151.2 MW codeine phosphate = 397.4 Number of protons in t-butyl group = 9... 

From the above data calculate the percentage of stated content for paracetamol and codeine phosphate. 

Capsules 50 mg butalbifal, 40 mg caffeine, 325 mg acefaminophen, and 30 mg codeine phosphate (Fioricet with Codeine)... 

Capsules 50 mg butalbital, 40 mg caffeine, 325 mg aspirin, 30 mg codeine phosphate (Ascomp with Codeine No.3, Butalbital Compound with Codeine, Butinal with Codeine No.3, Fiorinal with Codeine No.3, Idenal with Codeine, Isollyl with Codeine). 

Although codeine is manufactured in formulations in which it is the sole active ingredient (codeine phosphate oral... 

Natural opium alkaloids codeine phosphate hydromorphone hydrochloride morphine hydrochloride morphine sulfate oxycodone hydrochloride oxymorphone hydrochloride... 

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