Phenelzine sulfate

Therapeutic Function Psychostimulant Chemical Name (2-phenethyl)hydra2ine sulfate Common Name — 

Patent 3,000,903 September 19, 1961 assigned to Lakeside Laboratories, 

Chemical Name 3,3-Dimethyl-7-oxo-6-[(1-oxo-2-phenoxypropyl)amino] -4-thia-1-azabicy-cyclo[3.2.0] heptane-2-carboxylic acid potassium salt 

Trade Name Manufacturer Country Year Introducad 

Peniplus Penopen Penorale Synth ecilline Synthepen 

Beecham Research Laboratories, Ltd. British Patent 877,120 September 13, 1961 

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Narcotan - Halothane Narco26p Flunitrazepam Nardeizine Phenelzine sulfate Nardil - Phenelzine sulfate Narest Valethamate bromide Narigix Nalidixic acid Narsis - Medazepam Nasafarma - Oxymetazoline HCI Nazalide Flunisolide Nasal Yer Naphazoline Nasin Tetrahydrozoline HCI Nasivin - Oxymetazoline HCI Nasky Inositol niacinate Nasmil - Cromolyn sodium Nasophen - Phenylephrine HCI Natacillin - Hetacillln potassium Natacyn - Natamycin Natam - Flurazepam... 

Tranylcypromine sulfate is an antidepressant drug and an inhibitor of MAO. Its antidepressant effect is probably due to the accumulation of NE in the brain as a consequence of inhibition of the enzyme. The other MAO I currently used as an antidepressant is phenelzine sulfate. 

Phenazopyridine hydrochloride, 3,465 Phenelzine sulfate, 2,383 Phenformin hydrochloride, 4, 319 5,429 Phenobarbital, 7, 359... 

Monoamine oxidase (MAO) inhibitors, nonselective (Types A,B) phenelzine sulfate tranylcypromine sulfate... 

Weak bases and their salts (nortriptyline hydrochloride, phenelzine sulfate, chloroquine phosphate, scopolamine hydrobromide, tamoxifen citrate, etc.) approximately 45%... 

Phenelzine Sulfate, U5P. Phenelzine sulfate, 2-(phe-nylethyl)hydra/ine sulfate (Nardil), is an effective antidc-pre.ssant agent. A mechanism-based inactivator, it irreversibly inactivates the enzyme or its cofactor. pre.sumably after oxidation to the diazine, which can then bre up into molecular nitrogen, a hydrogen alum, and a phenethyl free radical. The latter would be the active species in irreversible inhibition. ... 

PSYCHOTROPIC, and also a veterinary immobilizing agent. It is a drug of abuse, largely withdrawn from human clinical use. phencyclidine hydrochloride phencyclidine, phenelzine [ban, inn] (phenelzine sulfate [usan] Nardil ) is one of the hydrazine class and is an irreversible MONOAMINE-OXIDASE INHIBITOR (MAOl active against both A and 6) used as an ANTIDEPRESSANT. 

Monoamine oxidase inhibitors (MAOI) Neurotransmitters norepinephrine, dopamine, epinephrine, and serotonin are inactive by the enzyme monoamine oxidase. MAOI inhibits monoamine oxidase, resulting in a rise in the levels of these neurotransmitters. MAOI are isocarboxazid (Marplan), phenelzine sulfate (Nardil), and tranylcypromine sulfate (Parnate). 

Antidepressants are divided into the following classes the dibenzapine derivatives are called tricyclic antidepressants and include imipramine (Tofranil), desipramine (Norpramin), amitriptyline (Elavil), nortriptyline (Aventyl), protriptyline (Vivactil), and doxepin (Adapin). The monoamine oxidase inhibitors are nsed occasionally to treat depression. The hydrazine derivatives consist of isocarboxazid (Marplan) and phenelzine sulfate (Nardil). The nonhydrazine derivatives inclnde tranylcypromine (Parnate). L-Tryptophan is the only member of the monoamine precnrsors nsed to treat depression. The newer and second-generation antidepressants inclnde amoxapine, doxepin, flnoxetine, maprotiline, trazodone, mianserin, alprazolam, and bnpropion (see also Tables 5 throngh 7). 

The monoamine oxidase inhibitors are used occasionally to treat depression. The hydrazine derivatives consist of isocarboxazid (Marplan) and phenelzine sulfate (Nardil). The nonhydrazine derivatives include tranylcypromine (Parnate). 

Monoamine oxidase inhibitor (MAOI) antidepressants have been in use for nearly 40 years. At the present time, they are viewed as second- or third-line antidepressant medications for reasons of both efficacy and safety. The available MAOIs are phenelzine sulfate (Nardil), isocarboxazid (Marplan), and tranylcypromine sulfate (Parnate). Two additional MAOI antidepressants, moclobemide and brofaromine, are approved for use in Europe and/or Canada. 

Certain t) es of foods can adversely effect the dmg s therapeutic effect by increasing absorption, delaying absorption, and even preventing absorption of the medication. Furthermore, food may cause the patient to experience an adverse reaction as in the case with phenelzine sulfate (Nardil), which is an MAO monoamineoxidase inhibitor anti-depressant. Nardil caimot be given with foods that use bacteria or molds in their preparation or for preservation of those that contain tyramine, such as cheese, sour cream, beer, wine, figs, raisins, bananas, avocados, etc. The nurse must assess if the dmg has a contraindication with food and educate the patient about this food-dmg interaction. 

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