Phenazopyridine hydrochloride

Molecular formula C11H12CIN5 Molecular weight 249.71 CAS Registry No 136-40-3 Merck Index 13, 7296 

Sample preparation Vigorously mix 1 mL plasma, 50 xL 40 p.g/mL IS, 200 p,L 100 mM NaOH, and 4 mL MTBE, centrifuge at 3000 rpm for 5 min. Evaporate the organic layer to dr3mess under a stream of nitrogen, reconstitute the residue with 1 mL 20 mM phosphoric acid, inject an 80 xL aliquot. 

Mobile phase MeCN 20 mM pH 2.7 potassium dihydrogen phosphate buffer 30 70 Flow rate 1.5 Injection volume 80 Detector UV 405 

Internal standard diltiazem (UV 238) (3.9) Limit of detection 10 ng/mL Limit of quantitation 50 ng/mL 

Kitzes-Cohen, R. Determination of phenazopyridine in human plasma by hi performance liquid chromatography, Chromatographia, 2000, 52, 179-180. 

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Phenazopyridine hydrochloride, 3,465 Phenelzine sulfate, 2,383 Phenformin hydrochloride, 4, 319 5,429 Phenobarbital, 7, 359... 

Therapeutic Function Urinary analgesic, Antiseptic, Diagnostic aid Chemical Name 2,6-Pyridinediamine, 3-(phenylazo)-, monohydrochloride Common Name Phenazopyridine hydrochloride Azopirin Chemical Abstracts Registry No. 94-78-0 (Base) 136-40-3... 

Soluble 1 in 300 of cold water, 1 in 20 of boiling water, 1 in about 60 of ethanol, and 1 in about 330 of chloroform very slightly soluble in ether soluble in glacial acetic acid. Phenazopyridine hydrochloride readily forms supersaturated aqueous solutions which deposit slowly on storage. 

Green ED, Zimmerman RC, Ghurabi WH, Colohan DP. Phenazopyridine hydrochloride toxicity a cause of drug-induced methemoglobinemia. JACEP 1979 8(10) 426-31. 

Phenazopyridine Hydrochloride. USP. Phenazopyri-dinc hydrochloride. 2.6-diamino-3-(phenylazopyri(linc hydrochloride (Pyridium). is a brick-red fine crystalline powder. It is slightly soluble in alcohol, in chloroform, and in water. 

Mercieca JE, Clarke ME, and Phillips ME (1982) Acute haemolytic anaemia due to phenazopyridine hydrochloride in G-6-PD deficient subject. Lancet 2 564. 

WJ Johnson, A Chartrand. The metabolism and excretion of phenazopyridine-hydrochloride in animals and man. Toxicol Appl Pharmacol 37 371—376, 1976. 

Urinary analgesics such as phenazopyridine hydrochloride are used frequently by many clinicians. If the pain or dysuria present in a UTI is a consequence of infection, then minary analgesics have little clinical role because most patients symptoms respond quite rapidly to appropriate antibacterial therapy. Urinary analgesics also may mask signs and symptoms of UTIs not responding to antimicrobial therapy. 

PHENAZOPYRIDINE HYDROCHLORIDE (Azo-Standard tablets 95 mg, Baridium tablets 100 mg, Geridium tablets 100 mg, tablets 200 mg, Prodium tablets 95 mg, Pyridiate tablets 100 mg, Pyridium tablets 100 mg, tablets 200 mg, Pyridium Plus tablets 150 mg, Urodine tablets 100 mg, tablets 200 mg, Urogesic tablets 100 mg, UTI Relief tablets 97.2 mg)... 

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