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Pharmaceutical industry drug discovery

Ivanisevic I, Bates S, Chen P (2009) Novel methods for the assessment of miscibility of amorphous drug-polymer dispersions. J Pharm Sci 98 3373-3386 Ivanisevic I, McClurg RB, Schields PJ, Gad SC (2010) Uses of X-ray powder diffraction in the pharmaceutical industry drug discovery, development, and manufacturing, pharmaceutical sciences... [Pg.475]

The accidental discovery of penicillin in 1928 by Alexander Fleming and its introduction in 1941/42 as an efficient antibacterial drugbearingno substantial side effects revolutionized medicinal chemistry and pharmaceutical research by stimulating completely new strategies in industrial drug discovery. Penicillin... [Pg.106]

Combinatorial chemistry, a new chapter of organic synthesis, is now developing rapidly. This new approach to synthesizing large designed or random chemical libraries through application of solid phase synthetic methods, promises to revolutionize the process of drug discovery in the pharmaceutical industry.24... [Pg.13]

The foundation for the more rational approach to drug discovery that is practised today comes from basic research into disease processes and medical conditions. Much of this research is carried out in universities and other research institutions, with funding coming from both government and pharmaceutical industry sponsors. [Pg.47]

Owing to the personal interest and experience of the authors, the emphasis in this chapter is on using computers for drug discovery. But the use of computers in laboratory instruments and for analysis of experimental and clinical data is no less important. This chapter is written with young scientists in mind. We feel it is important that the new investigator have an appreciation of how the field evolved to its present circumstance, if for no other reason than to help steer toward a better future for those scientists using or planning to use computers in the pharmaceutical industry. [Pg.4]

The 1990s was a decade of fruition because the computer-based drug discovery work of the 1980s yielded an impressive number of new chemical entities reaching the pharmaceutical marketplace. We elaborate on this statement later in this section, but first we complete the story about supercomputers in the pharmaceutical industry. [Pg.27]

As the twentieth century came to a close, the job market for computational chemists had recovered from the 1992-1994 debacle. In fact, demand for computational chemists leaped to new highs each year in the second half of the 1990s [135]. Most of the new jobs were in industry, and most of these industrial jobs were at pharmaceutical or biopharmaceutical companies. As we noted at the beginning of this chapter, in 1960 there were essentially no computational chemists in industry. But 40 years later, perhaps well over half of all computational chemists were working in pharmaceutical laboratories. The outlook for computational chemistry is therefore very much linked to the health of the pharmaceutical industry itself. Forces that adversely affect pharmaceutical companies will have a negative effect on the scientists who work there as well as at auxiliary companies such as software vendors that develop programs and databases for use in drug discovery and development. [Pg.40]

Schmid EF, Smith DA. Is declining innovation in the pharmaceutical industry a myth Drug Discovery Today 2005 10 1031-9. [Pg.50]

The new major challenge that the pharmaceutical industry is facing in the discovery and development of new drugs is to reduce costs and time needed from discovery to market, while at the same time raising standards of quality. If the pharmaceutical industry cannot find a solution to reduce both costs and time, then its whole business model will be jeopardized The market will hardly be able, even in the near future, to afford excessively expensive drugs, regardless of their quality. [Pg.67]

Ruffolo R. Re-engineering discovery and development impact on the pharmaceutical industry of tomorrow. In Drug Discovery Technology Europe 2005, IBC Life Sciences. [Pg.272]

Influencing the efficacy or potency of chemicals is a strategy used by the pharmaceutical industry as part of the drug discovery process that can be incorporated into designing safer industrial chemicals. Efficacy is the maximal effect, either therapeutic or toxic, that a chemical can achieve. Potency is a measure of the amount of a substance that is needed to attain a given response level. Opioid analgesics are examples of where structural modifications have been used to establish a relationship between structure and activity. ... [Pg.35]


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