Perspectives and Future Work

The idea in Fig. 6.12 is to prepare a light-responsive schizophrenic diblock (AB) copolymer micelle using azobenzene that is, the core- and shell-forming blocks can be reversed upon illumination at two different wavelengths. Ames et al. first 

CHAPTER 6 AZOBENZENE CONTAINING BLOCK COPOLYMER MICELLES 

Arotcarena M, Heise B, Ishaya S, Laschewsky A. 2002. Switching the inside and the outside of aggregates of water soluble block copolymers with double thermoresponsivity. J Am Chem Soc 124 3787 3793. 

Fukushima S, Harada A, Kataoka K. 2003. Design of environment sensitive supramolecular assemblies for intracellular drug delivery polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed Engl 42 4640 4643. 

Bellomo EG, Wyrsta MD, Pakstis L, Pochan DJ, Deming TJ. 2004. Stimuli responsive polypeptide vesicles by conformation specific assembly. Nat Mater 3 244 248. 

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E. Perspectives and Future Work V. Protein-Protein Interactions... 

In the next section a brief layout of simulation methods will be given. Then, some basic properties of the models used in computer simulations of electrochemical interfaces on the molecular level will be discussed. In the following three large sections, the vast body of simulation results will be reviewed structure and dynamics of the water/metal interface, structure and dynamics of the electrolyte solution/metal interface, and microscopic models for electrode reactions will be analyzed on the basis of examples taken mostly from my own work. A brief account of work on the adsorption of organic molecules at interfaces and of liquid/liquid interfaces complements the material. In the final section, a brief summary together with perspectives on future work will be given. 

In this review we will address mostly the developments of the past twelve years, characterized hy substantial progress in quahtative as well as quantitative understanding of the various instahilities. After introducing and explaining the basic equations (Section 13.2) the theoretical concepts of the linear and weakly non-Unear analysis will be presented (Section 13.3). In Section 13.4 and Section 13.5 the results for the two systems, introduced above, are discussed in particular in the hght of recent experiments. Finally, we will list topics which are omitted due to space limitations and we comment on some perspectives for future work (Section 13.6). 

The rest of the paper is structured as follows first, section 2 summarizes related work. In section 3, an example system is introduced to illustrate the problem of loops for integrated safety analysis models. In section 4, DSMs are used to overcome this problem by re-clustering the component hierarchy. Section 5 summarizes this paper and provides a perspective for future work. 

This paper is structured as follows Section 2 presents related work about security evaluation and introduces our approach. Section 3 describes our modeling approach in details and presents the first results obtained. Section 4 presents the main conclusions and some perspectives for future work. 

Section 3). The discussion of validation studies and applications (Section 4) will start with chemical shifts of ligand atoms, continue with metal shifts, and close with a few examples on spin-spin coupling constants. A summary and a perspective for future work are given in Section 5. 

Perspectives for future work will focus on dynamic modeling and advanced control techniques (predictive and adaptive) to provide better navigation performance of the vehicle. The aim is to also include other navigation sensors such as sonar and a gyroscope to improve the location system of the submarine. 

We will then examine other flexible polymer crystallization instances which may be interpreted, at least qualitatively, in terms of the bundle model. We will concentrate on crystallization occurring through metastable mesophases which develop by quenching polymers like isotactic polypropylene, syndiotactic polypropylene etc. In principle also hexagonal crystallization of highly defective polymers, and order developing in some microphase-separated copolymer systems could be discussed in a similar perspective but these two areas will be treated in future work. A comparison between the bundle approach and pertinent results of selected molecular simulation approaches follows. 

Summary. Two principal methods for removal of low frequency noise transients are currently available. The model-based separation approach has shown more flexibility and generality, but is computationally rather intensive. It is felt that future work in the area should consider the problem from a realistic physical modelling perspective, which takes into account linear and non-linear characteristics of gramophone and film sound playback systems, in order to detect and correct these artifacts more effectively. Such an approach could involve both experimental work with playback systems and sophisticated non-linear modelling techniques. Statistical approaches related to those outlined in the click removal work (section 4.3.4) may be applicable to this latter task. 

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