Peptides, development

D. H. Schlesinger, ed.. Neurohypophyseal Peptide Hormones and Other Biologically Active Peptides, Developments in Endocrinology, Vol. 13, Elsevier Science, New York, 1981. 

The PAR-3 subtype of the PAR family is truncated at the C-terminus limiting its potential to signal intracel-lularly. Furthermore, other than thrombin, there have been no specific activating peptides developed that... 

Hydrogen abstraction by ketone sensitizers forms the basis of an elegant alkylation procedure for ethers, amides, lactones, amino acids, and peptides developed by Elad and his group.94 Terminal olefins, for example, can be added to y-butyrolactone (15) in good yield.95... 

Xing, L., Dawei, C., Liping, X., and Rongqing, Z. Oral colon-specific drug delivery for bee venom peptide Development of a coated calcium alginate gel beads-entrapped liposome. J. Contr. Rel. 93 293—300, 2003. 

Fletcher, M. D., Campbell, M. M. Partially Modified Retro-Inverso Peptides Development, Synthesis, and Conformational Behavior. Chem. Rev. 1998, 98, 763-796. 

TABLE 22.1 Overview of studies used to support peptide development... 

Fleet s carbopeptoids are closely related to the oligo tetrahydrofuran amino acid sequence used in the gramicidin-like peptide developed and studied by Koert and co-workers.364 These oligo-THF peptides (Figure 52) were inserted into synthetic lipid bilayer... 

K. C. (submitted) Facile synthesis of multimeric peptides development of cell-specific delivery systems. 

The laboratory of Stupp has made important contributions in understanding the self-assembly of alkylated yS-sheet PAs into cylindrical or spherical micelles and fibers.Nanomaterials based on the amphiphilic peptides developed by Stupp and coworkers have been successfully employed in a wide range of applications such as tissue repair, ery. 

An alternative route to Fc-peptides, developed by Beck and coworkers, uses ferrocenyl oxazolones, which can be obtained by the reaction of Fc-amino acids (19) with a carbodiimide (Scheme 5). The resulting oxazolone (20) undergoes a nucleophilic ring-opening reaction with the amino group of a C-protected amino acid to give the desired Fc-peptide (4). 

S. no. Protein/peptide Developing system Detection References... 

Major histocompatibility complex (MHC) Class 11 molecules are believed to bind to a 3 (IV) NCI epitopes stimulating T-cell recognition and modulating the humoral response. Using a mouse model of GBM disease, Kalluri and colleagues (30) showed that all mice strains immunized with a3 (IV) NCI peptides developed anti a3 (IV) NCI antibodies but the development of pulmonary and renal disease was restricted to Swiss James Lambert (SJL) mice that possessed MHC H-2 . B6 (H-2 ), BALB/c (H-2 ), DBA/2 (H-2 ) mice developed only renal disease and A/J (H-2 ), AKR (H-2 ), and CBA (H-2 ) mice showed no evidence of either renal or pulmonary disease. In addition, these investigators showed that passive transfer of isogenic a3 (IV) NCI antibodies into T-cell receptor-deficient mice did not cause renal or pulmonary injury. Further immunohistochemical studies supported a Thl response pattern with increased presence of interleukin (IL)-12, lL-4, IL-10, and... 

---