Peptide ligand development

Recently, nonpeptide compounds have been developed for many peptide receptor systems. These compounds, which usually are discovered through screening of chemical files, generally do not resemble the corresponding peptide ligands chemically. Nevertheless, they act as specific and... 

This relatively small DCL yielded the first peptidic ligand for G-quadruplex DNA, providing a lead compound for the further development of novel G-quadruplex ligands with possible therapeutic utility. 

Phage displayed peptide libraries have been snccessfnlly employed for the identification of peptide ligands with a variety of applications. Recent reviews describe the developments in the generation and screening of peptide libraries [6], their application in the identification of receptor ligands [32] and in drng development [33]. 

Fong S, Doyle LV, Devlin JJ, Doyle MV, Scanning whole cells with phage-display libraries identification of peptide ligands that modulate cell function, Drug Develop Res., 33 64-70, 1994. 

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