Peptide drugs development

Peptide hormones and neurotransmitters are primary agents of communication between different cell types In the body of complex living systems Including man. Thus, analogs of natural peptide hormones and neurotransmitters with appropriate properties have exceptional potential as drugs. Despite this potential and the need for peptide drugs, development has been slow. Why ... 

J.-C. Westermann and D. J. Craik, NMR in Peptide Drug Development , in Methods in Molecular Biology (Totowa, NJ, United States), ed. L. Otvos, Humana Press Inc., 2008, vol. 494, Peptide-Based Drug Design, p. 87. 

Recent developments in drug discovery and drug development spurred the need for novel analytical techniques and methods. In the last decade, the biopharmaceutical industry set the pace for this demand. The nature of the industry required that novel techniques should be simple, easily applicable, and of high resolution and sensitivity. It was also required that the techniques give information about the composition, structure, purity, and stability of drug candidates. Biopharmaceuticals represent a wide variety of chemically different compounds, including small organic molecules, nucleic acids and their derivatives, and peptides and proteins. 

During the past 10 years, one of the most exciting developments in the oral peptide drug delivery was the identification of PEPT1. This is a significant finding because this carrier protein is known to play a critical role in the absorption of... 

M. F. Powell, Peptide Stability in Drug Development In vitro Peptide Degradation in Plasma and Serum , Annu. Rep. Med. Chem. 1993, 28, 285-294 M. F. Powell, H. Grey, F. Gaeta, A. Sette, S. Colon, Peptide Stability in Drug Development a Comparison of Peptide Reactivity in Different Biological Media , J. Pharm. Sci. 1992, 81, 731-735. 

Bacterial resistance to conventional antibiotics has become a serious problem in infection control, and has led to intensive research efforts to develop an effective novel antimicrobial agent. Antimicrobial peptides have already played a crucial role in pharmaceutical research as biomedically useful agents or as lead compounds for drug development. More specifically, cyclic peptides have shown some potential as a possible new class of... 

In another example, the stability of a solution of a peptide drug shown in Figure 6.17, being developed as an injectable formulation development, was... 

Lowman, H. (1997). Bacteriophage display and discovery of peptide leads for drug development. Ann. Rev. Biophys. Biomol. Struct. 26, 401-424. 

T. Hedner, X. Sun, I. L. Junggren, A. Pettersson, L. Edvinsson (1992). Peptides as targets for antihypertensive drug development. J. Hypertem. 10 S121. 

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