Pediatric Pharmacology Research

Marshall J, Rodarte A, Blumer J, Khoo KC, Akbari B, Kearns G. Pediatric pharmacodynamics of midazolam oral syrup. Pediatric Pharmacology Research Unit Network. J Clin Pharmacol 2000 40(6) 578-89. 

The Pediatric Pharmacology Research Unit (PPRU) is a network of experienced clinical investigators committed to facilitating pharmacological research in the pediatric medical community (55). Acting as a consortium, the PPRU has the potential to provide access to... 

Information about the Pediatric Pharmacology Research Unit (PPRU) can be found by visiting their link through the National Institute of Child Health and Human Development Center for Research for Mothers and Children Endocrine, Nutrition, and Growth Branch, at http //www.nichd. nih.gov/crmc/eng/eng.htm. 

Edmund V. Capparelli, Pediatric Pharmacology Research Unit, School of Medicine, University of California—San Diego, 4094 4th Avenue, San Diego, CA 92103 and Trials by Design, 1918 Verdi Ct., Stockton, CA 95207 [ecapparelli ucsd.edu]... 

Pediatric Pharmacology Research Unit Network (2006). http //www.ppru.org/ (accessed January 2006). 

Gregory L. Kearns, PharmD, PhD Marion Merrell Dow/Missouri Chair in Medical Research, Professor of Pediatrics and Pharmacology, UMKC, Chair, Department of Medical Research, Associate Chairman, Department of Pediatrics, Chief, Division of Pediatric Pharmacology Medical Toxicology, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA... 

There remains a paucity of research on the psychopharmacology of childhood anxiety disorders. However, pediatric psychopharmacology research over the last decade (see Riddle et ah, 2001, for review) has begun to generate hypotheses on neurobiological mechanisms underlying childhood anxiety disorders. Such research raises interest in the role for pharmacological probes as precipitants of anxiety. 

Professor and Chairman, Ivey Chair in Molecular Toxicology, University of Western Ontario Director, The Motherisk Program, Professor of Pediatrics, Pharmacology, Pharmacy, Medicine, and Medical Genetics, The University of Toronto Senior Scientist, The Research Institute, The Hospital for Sick Children, Toronto... 

Special Aspects of Perinatal Pediatric Pharmacology Introduction Supported by a grant from The Canadian Institutes for Health Research. 

The traditional PK study volunteer study in healthy children has proved very hard to set up, because of the attitude of many parents and overviewing independent review boards (IRBs). Even in pediatric patients, the frequency and total volume requirements for samples for conventional PK studies can cause the same refusals. However, there are pediatric research units that specialize in these studies, with minimum needle sticks, minute blood volumes and IRBs sympathetic to the needs of the pediatric community. The National Institute of Child Health and Human Development has set up a network of pediatric pharmacology units , usually in academic regional centers, now... 

The face of pediatric pharmacologic medicine has been changed. In future, for pediatricians there will be less uncertainty and better predictive information available for children, safer and more effective dosages will result. For the industry, the added cost of research will be more than recouped in a new global market to which previously they could not promote their products. This is supported by the 1998 survey by PhRMA, which showed that medicines and vaccines in development for children were up 28% from the previous year. 

John T. Wilson, MD Professor of Pediatrics and Clinical Pharmacology, Department of Pediatrics, Section on Clinical Pharmacology, Director of the Children s Clinical Research Center, Louisiana State University Health Sciences Center, 1501 Kings Highway, PO Box 33932, Shreveport, LA 71130-3932, USA... 

Dr. Meskin s major areas of research interest include (1) hepatic drug metabolism and the effects of nutritional factors on drug metabolism and clearance (2) nutrient-drug interactions (3) the role of bioactive non-nutrients (phytochemicals, herbs, botanicals, and nutritional supplements) in disease prevention and health promotion (4) fetal pharmacology and fetal, maternal, and pediatric nutrition (5) nutrition education and (6) the development of educational programs for improving science literacy and combating health fraud. 

Toxicology and Applied Pharmacology Obstetrics and Gynecology British Medical Journal Pediatric Research Oyo Vakuri (Pharmacometrics)... 

Department of Pediatrics, Emory University School of Medicine, Laboratory of Biochemical Pharmacology (LOBP) VA Medical Center- Medical Research, 151H/5A-146 1670 Clairmont Road, Decatur, GA 30033 USA e-mail jnettle emory.edu... 

CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 Dana-Farber Cancer Institute, Departments of Pediatrics, Biological Chemistry and Molecular Pharmacology, Harvard Medical School,... 

MICHAEL ASCHNER, PhD Departments of Pediatrics and Pharmacology, Center in Molecular Toxicology and Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, TN 37212, USA... 

Pharmacogenomics explores the relationship between genetic variability and responses to pharmacological intervention. However in pediatrics, this area of research is in its infancy and only a small number of investigations linked to therapeutic response in children. This is mainly due to limited patient number, use of only a candidate gene approach, paucity of meta-analysis, use of different research methods across studies, lack of replication of studies, and... 

SHELDON M. SCHUSTER (44), Interdisciplinary Center for Biotechnology Research, University of Florida, College of Medicine, Gainesville, Florida 32610 ALAN L. SCHWARTZ (193, 199), Edward Mallinckrodt Departments of Pediatrics and Molecular Biology, and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110... 

Cheston M. Berlin Jr., M.D., is a university professor of pediatrics and professor of pharmacology at the Milton S. Hershey Medical Center at the Pennsylvania State University College of Medicine, Penn State Children s Hospital. His expertise and research interests are in pediatric nutrition, lactation, breastfeeding, drugs in human milk, failure to thrive, phenylketonuria, Tourette syndrome, drugs and nutrition, and caffeine. Dr. Berlin received his M.D. from Harvard Medical School. He is a member of the American Academy of Pediatrics, the American Society for Nutritional Sciences, and the American Society for Clinical Nutrition and is chair of the U.S. Pharmacopeia Immunizing Agents Expert Committee. 

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