Dosage effect

Ceballos-Picot, I., Nicole, A., Briand, P., Grimber, G., Delacourte, A., Defossez, A., Javoy-Agid, F., Lafon, M., Blouin, J.L. and Sinet, P.M. (1991). Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice animal model of gene dosage effects in Down s syndrome. Brain Res, 552, 198-214. 

Compounds with a 4-alkyl seem to produce the most severe sensory disruption. The prototype of these is DOM (Table 1), which received notoriety following its introduction into the illicit market in 1967. Extension of the alkyl to ethyl (DOET) and -propyl (DOPR) gives further potency increases (203). In early reports, the low dosage effect of DOET was characterized as nonhallucinogenic (211,215) it is clear, however, that this is dose dependent. 

Mann, D.M., Iwatsubo, T., Pickering-Brown, S.M., Owen, F., Saido, T.C., Perry, R.H. (1997) Preferential deposition of amyloid beta protein (Abeta) in the form of Abeta40 in Alzheimer s disease associated with a gene dosage effect of the apolipoprotein E E4 aUele. Neurosci. Lett., 221, 81-84. 

This model assumes that any dosage effect has the same mechanism as that which causes the background incidence. Low-dose linearity follows directly from this additive assumption, provided that any fraction of the background effect is additive no matter how small. A best fit curve is fitted to the data obtained from a long-term rodent cancer bioassay using computer programs. The estimates of the parameters in the polynomial are called Maximum Likelihood Estimates (MLE), based upon the statistical procedure used for fitting the curve, and can be considered as best fit estimates. Provided the fit of the model is satisfactory, the estimates of these parameters are used to extrapolate to low-dose exposures. 

Individual dosage - Effective use of theophylline is occurs when the theophylline concentration is maintained from 10 to 20 mcg/mL. 

Douglas, V., Barr, R., Amin, K., O Neill, M., Britton, B. (1988) Dosage effects and individual responsivity to methylphenidate in attention deficit disorder. / Child Psychol Psychiatry 29 453-475. 

Flipse, E., Keetels, C. J. A. M., Jacobson, E., Visser, R. G. F. (1996). The dosage effect of the wildtype GBSS allele is linear for GBSS activity, but not for amylose content absence of amylose has a distinct influence on thew physico-chemical properties of starch. Theor. Appl. Genetics, 92, 121-127. 

Tissue or Variable Effects at Therapeutic Dosage Effects at Toxic Dosage... 

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Increased fat and increased protein content in the mix delay adsorption of emulsifiers to air. Low temperature also has an inhibiting effect on this phenomenon. Surface tension analysis may be used to measure dosage effect in low-fat ice cream mixes. Such studies show that on a weight basis emulsifier is bound 10 times more strongly to fat than to milk protein in the mix49. 

Luo, W., Wolska, B.M., Grupp, I.L., etal., 1996, Phospholamban gene dosage effects in the mammalian heart. Circ Res, 78(5), pp839 17. 

Cronbach, L. J., Gleser, G. C., Loewe, S. Quantal and Graded Analysis of Dosage-Effect Relations. Science. 

Note Other methylated tryptamines with similar psychoactive properties include 6-fluoro-alpha-methyltrypta-5-methyltryptamine, N-methyltryptamine, 5-methyltryptamine. The dosage, effects, and contraindications are about the same for these as for the above. Some of the non-methylated derivatives are also active. These include 5-and 6-fluorotryptamine and 5- and 6-fluorotryptophan. 

Several hundred to several thousand 1 to 4 years Safety, dosage, effectiveness 25%-30%... 

Hurrtirrgtorr Study Group (2003) Dosage effects of riluzole in Huntirrgtorr s disease A multicerrter placebo controlled study. Neurology 61(11) 1551-1556. 

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