Pausinystalia

Paniculatine ex Celaslms panieulaia, 780 Paniculatine ex Pausinystalia panieulaia, 501, 502... 

Pausinystalia spp., 500, 501 Pa3rta bark pa3rtamine pa3rtine, 513 Pectenine, 159 Peganine. See Vasicine. 

Carbocyclic variants related to ajmalicine such as yohimbine are likely to arise from dehy-drogeissoschizine by the mechanism indicated in Figure 6.77. Yohimbine is found in Yohimbe bark (Pausinystalia yohimbe, Rubiaceae) and Aspidosperma bark (Aspidosperma species Apocy-naceae) and has been used in folk medicine as an aphrodisiac. It does have some pharmacological activity and is known to dilate blood vessels. More important examples containing the same carbocyclic ring system are the alkaloids found in species of Rauwolfla, especially R. serpentina (Apocynaceae). Reserpine and deserpi-dine (Figure 6.78) are trimethoxybenzoyl esters of yohimbine-like alkaloids, whilst rescinnamine is... 

Increased risk of hypertension is imminent when tricyclic antidepressants are combined with yohimbine (Pausinystalia yohimbe). 

Yohimbine Muscle relaxant Aphrodisiac Without Correlation Pausinystalia yohimbe... 

This "psychedelic stimulant" is derived primarily from the bark of a West African tree called Pausinystalia or Corynantheyohimbe, although it is also present in other species of Corynanthe and in Aspidosperma quebran-choblanco and Mitragyna stipulosa. When this alkaloid is brewed as a tea and then drunk, its effects come on within forty-five minutes to an hour. The action is reportedly swifter if taken with 500 mg. vitamin C... 

Recent extractions440 of the leaves of Cinchona ledgeriana have resulted in the isolation of quinamine (previously observed), 3-ep/-quinamine, aricine, and a new alkaloid which may prove to be stereoisomeric with quinamine. 11-Hydroxy-pleiocarpamine occurs in Vinca erecta 4b and herbacine and herbaine in V. herbacea.44c Yohimbine appears to be the major alkaloid of the trunk bark of Pausinystalia macroceras, in which it occurs with four other alkaloids of this group.44d Pleiocarpamine occurs in association with nine alkaloids of the aspidospermine-eburnamine group in the stem and root bark of Hunteria elliottii (Stapf.) Pichon.44e... 

Calycanthine has been isolated44 from Pausinystalia macroceras this is the first report of the occurrence of this alkaloid in this genus. 

Pausinystalia yohimbe Pierre (Corynanthe johimbe K. Sehum.)... 

Mebdinus balansae, Rauwolfia serpentina [root], R. spp., Tonduzia longfolia (Apocynaceae), Pausinystalia johimbe (Rubiaceae)... 

Y ohimbine Treatment of impotence Pausinystalia johimbe Yohimbe... 

Yohimbine is a major carboline alkaloid in the bark of Pausinystalia species, such as Pausinystalia yohimbe (Corynanthe yohimbe), Pausinystalia macrocerus, Pausinystalia paniculata, and Pausinystalia trillesi. It is also found in Pseudocinchona africana and Rauwolfia canescens. 

Yohimbe (Pausinystalia yohimbe) is a purported aphrodisiac that contains a number of alkaloids, including yohimbine. This compound has been used in prescription formulations as a treatment for certain types of impotence (Sonda et al., 1990) but has been reported to cause serious adverse reactions (Grossman et al., 1993). Despite the potency of yohimbine itself, there have been no reports of an adverse reaction to yohimbe in the peer-reviewed hterature. This lack of adverse reactions to yohimbe products in the United States is probably due to the very low levels (or absence) of alkaloids in dietary supplement products on the market, and adverse reactions would be expected if alkaloid levels in products were increased by manufacturers (Betz et al., 1995). 

Source Pausinystalia yohimbe. Molecular formula C21 H26 N 2 O3. Molecular weight 354.99. 

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