Yohimbe, Pausinystalia

Carbocyclic variants related to ajmalicine such as yohimbine are likely to arise from dehy-drogeissoschizine by the mechanism indicated in Figure 6.77. Yohimbine is found in Yohimbe bark (Pausinystalia yohimbe, Rubiaceae) and Aspidosperma bark (Aspidosperma species Apocy-naceae) and has been used in folk medicine as an aphrodisiac. It does have some pharmacological activity and is known to dilate blood vessels. More important examples containing the same carbocyclic ring system are the alkaloids found in species of Rauwolfla, especially R. serpentina (Apocynaceae). Reserpine and deserpi-dine (Figure 6.78) are trimethoxybenzoyl esters of yohimbine-like alkaloids, whilst rescinnamine is... 

Increased risk of hypertension is imminent when tricyclic antidepressants are combined with yohimbine (Pausinystalia yohimbe). 

Yohimbine Muscle relaxant Aphrodisiac Without Correlation Pausinystalia yohimbe... 

Pausinystalia yohimbe Pierre (Corynanthe johimbe K. Sehum.)... 

Catharanthus lanceus, Rauwofia serpentina (Apocynaceae), Pausinystalia yohimbe (Rubiaceae) [yohimbe bark]... 

Yohimbine is a major carboline alkaloid in the bark of Pausinystalia species, such as Pausinystalia yohimbe (Corynanthe yohimbe), Pausinystalia macrocerus, Pausinystalia paniculata, and Pausinystalia trillesi. It is also found in Pseudocinchona africana and Rauwolfia canescens. 

Yohimbe (Pausinystalia yohimbe) is a purported aphrodisiac that contains a number of alkaloids, including yohimbine. This compound has been used in prescription formulations as a treatment for certain types of impotence (Sonda et al., 1990) but has been reported to cause serious adverse reactions (Grossman et al., 1993). Despite the potency of yohimbine itself, there have been no reports of an adverse reaction to yohimbe in the peer-reviewed hterature. This lack of adverse reactions to yohimbe products in the United States is probably due to the very low levels (or absence) of alkaloids in dietary supplement products on the market, and adverse reactions would be expected if alkaloid levels in products were increased by manufacturers (Betz et al., 1995). 

Source Pausinystalia yohimbe. Molecular formula C21 H26 N 2 O3. Molecular weight 354.99. 

Yohimbine (yocon), a competitive a2 antagonist, is an indolealkylamine alkaloid found in the bark of the tree Pausinystalia yohimbe and in Rauwolfia root structurally, yohimbine resembles reserpine. 

Sitsirikine and/or isositsirikine have since been found in Aspidosperma ohlongum A. DC. (32) and dihydrositsirikine has been isolated from Pausinystalia yohimbe Pierre (35). Cavincine and cathindine (13) are also believed (22) to be relatives of sitsirikine. 

Ajayi, A.A., M. Newaz, H. Hercule, et al. 2003. Endothelin-like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. Methods Find. Exp. Clin. Pharmacol. 25(10) 817-822. 

Chen, Q., P. Li, Z. Zhang, et al. 2008. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass sp>ectrometry. /. Sep. Sci. 31(12) 2211-2218. 

Yohimbine Pausinystalia yohimbe Eieerile dysfunction treatment... 

Yohimbine is obtained naturally in Pausinystalia yohimbe, Rauwolfia serpentina, and Alchomia floribanda. The tree is native to the coastal forests of Central Africa... 

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