Pausinystalia Yohimbine

Carbocyclic variants related to ajmalicine such as yohimbine are likely to arise from dehy-drogeissoschizine by the mechanism indicated in Figure 6.77. Yohimbine is found in Yohimbe bark (Pausinystalia yohimbe, Rubiaceae) and Aspidosperma bark (Aspidosperma species Apocy-naceae) and has been used in folk medicine as an aphrodisiac. It does have some pharmacological activity and is known to dilate blood vessels. More important examples containing the same carbocyclic ring system are the alkaloids found in species of Rauwolfla, especially R. serpentina (Apocynaceae). Reserpine and deserpi-dine (Figure 6.78) are trimethoxybenzoyl esters of yohimbine-like alkaloids, whilst rescinnamine is... 

Increased risk of hypertension is imminent when tricyclic antidepressants are combined with yohimbine (Pausinystalia yohimbe). 

Yohimbine Muscle relaxant Aphrodisiac Without Correlation Pausinystalia yohimbe... 

Recent extractions440 of the leaves of Cinchona ledgeriana have resulted in the isolation of quinamine (previously observed), 3-ep/-quinamine, aricine, and a new alkaloid which may prove to be stereoisomeric with quinamine. 11-Hydroxy-pleiocarpamine occurs in Vinca erecta 4b and herbacine and herbaine in V. herbacea.44c Yohimbine appears to be the major alkaloid of the trunk bark of Pausinystalia macroceras, in which it occurs with four other alkaloids of this group.44d Pleiocarpamine occurs in association with nine alkaloids of the aspidospermine-eburnamine group in the stem and root bark of Hunteria elliottii (Stapf.) Pichon.44e... 

Yohimbine is a major carboline alkaloid in the bark of Pausinystalia species, such as Pausinystalia yohimbe (Corynanthe yohimbe), Pausinystalia macrocerus, Pausinystalia paniculata, and Pausinystalia trillesi. It is also found in Pseudocinchona africana and Rauwolfia canescens. 

Yohimbe (Pausinystalia yohimbe) is a purported aphrodisiac that contains a number of alkaloids, including yohimbine. This compound has been used in prescription formulations as a treatment for certain types of impotence (Sonda et al., 1990) but has been reported to cause serious adverse reactions (Grossman et al., 1993). Despite the potency of yohimbine itself, there have been no reports of an adverse reaction to yohimbe in the peer-reviewed hterature. This lack of adverse reactions to yohimbe products in the United States is probably due to the very low levels (or absence) of alkaloids in dietary supplement products on the market, and adverse reactions would be expected if alkaloid levels in products were increased by manufacturers (Betz et al., 1995). 

Yohimbine (yocon), a competitive a2 antagonist, is an indolealkylamine alkaloid found in the bark of the tree Pausinystalia yohimbe and in Rauwolfia root structurally, yohimbine resembles reserpine. 

Chen, Q., P. Li, Z. Zhang, et al. 2008. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass sp>ectrometry. /. Sep. Sci. 31(12) 2211-2218. 

Yohimbine is derived from the bark of Aspidosperma quebracho (Apocynaceae) and Pausinystalia yohimba (Rubiaceae). These plants are reputedly aphrodisiacs. Yohimbine blocks a-adrenergic transmissions but stimulates p-adrenergic sites (Robinson 1981). Yohimbine and strychnine are sometimes combined in pharmaceutical preparations for use as aphrodisiacs and nerve tonics. 

Yohimbine Pausinystalia yohimbe Eieerile dysfunction treatment... 

Yohimbine is obtained naturally in Pausinystalia yohimbe, Rauwolfia serpentina, and Alchomia floribanda. The tree is native to the coastal forests of Central Africa... 

Yohimbine Pausinystalia yohimbe NACE 30 mM ammonium acetate, 0.5 % acetic acid in methanol UV at 220 nm [65]... 

Corynanthe yohimbe (Pausinystalia yohimbe Rubiaceae) is a evergreen tree native to the southern part of Africa and to Cameroon, Nigeria, and Zaire. Occasionally it is planted in tropical countries. Its bark coontains a total of 0.3%-1.5% alkaloids. The well known indole alkaloid yohimbine has been obtained as a major alkaloid from the bark. The bark has been used traditionally as an aphrodisiac by African natives. Yohimbine hydrochloride is used as an adrenergic blocker for humans. 

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