Bark, yohimbe

Processes for the isolation and purification of yohimbine have been described by Thoms, Feldhoff, Chemnitius, Schwyzer, Raymond-Hamet and others. Some of these processes have been modified to provide for estimation of the yield of yohimbine, usually as the hydrochloride, from the bark, or to facilitate the identification of this alkaloid in commercial yohimbe bark, which is apt to vary both in quality and in botanical origin.According to Witkop (1943) modern technical yohimbine hydrochloride may contain a little isoyohimbine but no allo-yohimbine. 

Yohimbe bark improves sexual performance in males... 

Yohimbe bark Centrally active antihypertensive agents Yohimbine (a major alkaloid in yohimbe bark) may antagonize guanabenz and the methyldopa metabolite through its oj-adrenoceptor antagonistic properties. 

Carbocyclic variants related to ajmalicine such as yohimbine are likely to arise from dehy-drogeissoschizine by the mechanism indicated in Figure 6.77. Yohimbine is found in Yohimbe bark (Pausinystalia yohimbe, Rubiaceae) and Aspidosperma bark (Aspidosperma species Apocy-naceae) and has been used in folk medicine as an aphrodisiac. It does have some pharmacological activity and is known to dilate blood vessels. More important examples containing the same carbocyclic ring system are the alkaloids found in species of Rauwolfla, especially R. serpentina (Apocynaceae). Reserpine and deserpi-dine (Figure 6.78) are trimethoxybenzoyl esters of yohimbine-like alkaloids, whilst rescinnamine is... 

Catharanthus lanceus, Rauwolfia serpentina (Apocvnaceae), Pausinystaliayohim.be (Rubiaceae) [yohimbe bark]... 

Rauwolfia serpentina (Apocynaceae), Pausinystaliayohimbe (Rubiaceae) [yohimbe bark] Annona glabra, A. spp. (Annonaceae), Cryptocarya odorata (Lauraceae), Papaver somniferum (opium poppy latex), P spp. (Papaveraceae),... 

Herbal substitutes for dru [s of abuse A variety of herbal mixtures are offered for sale in magazines, on the internet and in so-called smart , eco or head shops. Many are marketed as herbal Ecstasy and the plants included in the formulations include Yohimbe bark, Kava-Kava (Piper methysticum),Y-3 e.emi, Hops, Jaborandi and Alisma. One product contains Kava-Kava, Guarana, Uva Ursi and Cascara bark. Many of the products sold as herbal Ecstasy contain either Ephedra sinica (Ma huang) or the Indian plant Sida cordifolia which both contain the alkaloid ephedrine (see R03c, Chapter VI). Other alkaloids may also occur, such as pseudoephedrine, norephedrine and norpseudoephedrine. The side-effects of ephedrine include tachycardia, anxiety, insomnia and arrythmias and a hypotensive crisis may develop if monamine oxidase inhibitors are also taken. Many adverse reactions and more than 20 deaths have been attributed to ephedrine and Ephedra consumption. Research conducted in the US shows that the daily intake of some Ephedra products would give ephedrine levels well above the recommended therapeutic doses. 

Q My friend gave me some yohimbe bark to make sex more fun. I used it 3-4 times a day for about a month. At first it seemed to make sex more "sensitive" but that went away after about a week. I ran out of the bark and want to get more Not for sex, but because I think it made me lose a lot of bodyfat. Does that make sense. 

Yohimbine, an indole alkaloid isolated from PausinystUa yohimbe bark and Rauwolfia roots is an a2-antagonist with greater selectivity for q2- than for... 

Ajmalicine (7) was first isolated from yohimbe bark and, later, from Rauvolfia species. This compound is one of the principal alkaloids of Catharanthus roseus. Ajmalicine is found in members of both the Apocynaceae and Rubiaceae. Approximately 3600 kg are produced each year at a market price of about 2000/kg (Verpoorte et al., 1991). 

Ajtnalicine is found in plants belonging to Apocynaceae, namely, Catharanthus roseus, Rauwolfia serpentina, and Rauwolfia vomitoria. Ajmalicine was first isolated from yohimbe bark and is one of the principal alkaloids of Catharanthus roseus and widely used to treat circulatory disorders [6] (Fig. 20.3). Ajmalicine is... 

---