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Asthma paracetamol

In susceptibie individuais, NSAIDs may precipitate acute bronchospasm. It affects 10-20% of adults with asthma but is rare in asthmatic children. The mechanism is related to cyclooxygenase inhibition, with shunting of arachidonic acid metabolism from the prostaglandin pathway to the biosynthesis of ieukotrienes with increased mucosal permeability and bronchospasm. Susceptible patients should avoid NSAIDs since the bronchospasm may be severe and has been fatal. Paracetamol in doses up to 1000 mg daiiy wiii be toierated by most patients. True type I allergic reactions to NSAIDs, with specific IgE, are rare but anaphyloactoid reactions have occasionally been described in patients with a history of aiiergy or bronchiai asthma. [Pg.135]

Aspirin-induced asthma has an onset of 30 minutes to 3 hours after ingestion. Affected individuals are cross-sensitive to all non-steroidal anti-inflammatory drugs (NSAIDs). Paracetamol is seldom associated with cross-sensitivity in patients with aspirin-induced asthma. Aspirin-induced asthma is believed to involve inhibition of COX-1. Patients should be provided with information on which drugs these are. [Pg.76]

A 2-year-old girl with a past history of asthma, developmental delay, short neck, and lumbar lordosis, but no known genetic defect or syndrome underwent anesthesia with midazolam and paracetamol premedication, halothane and nitrous oxide induction, and isoflurane plus nitrous oxide for maintenance of anesthesia. Difficulty with mouth opening was noted and endotracheal intubation was difficult. Limb rigidity developed rapidly. Thiopental and cisatracurium were given and the muscle rigidity abated over the next 10 minutes. [Pg.1495]

An observational study, part of a population-based case-control study of dietary antioxidants and asthma, has shown an association between the regular use of paracetamol and the incidence of asthma and rhinitis in adults (10). After controlling for potential confounding factors the OR for asthma in daily users, compared with never users, was 2.38 (Cl = 1.22,4.64). Not unexpectedly, there was also an association in users and non-users of aspirin, strongest when cases with more severe disease were compared with controls. This adverse effect of paracetamol may be due to depletion of the antioxidant glutathione in the lungs. However, further studies are needed before paracetamol can be blamed for an increase in the prevalence and severity of asthma. [Pg.2680]

Shaheen SO, Sterne JA, Songhurst CE, Burney PG. Frequent paracetamol use aud asthma iu adults. Thorax 2000 55(4) 266-70. [Pg.2690]

Parvolex ) is used a MUCOLYTIC agent, which reduces the viscosity of sputum, so can be used as an expectorant in patients with disorders of the upper respiratory airways, such as chronic asthma and bronchitis. It is also used orally to treat abdominal complications associated with cystic fibrosis, and locally in the eye to increase lacrimation and mucus secretion. It is also used intravenously as an antidote in paracetamol poisoning. [Pg.4]

Drugs containing phenolic groups include the analgesics morphine (and related opiates) and paracetamol as well as the bronchodilator salbutamol, widely used in the treatment of acute asthma. See Figure 8.9. [Pg.210]

The effect of reduction in antioxidant activity has been explored in another way, by exposure to paracetamol, which depletes the antioxidant glutathione. In adults in Britain there was a positive relationship between paracetamol use and asthma [89(111)]. Paracetamol sales per capita have been examined in relationship to ISAAC data in 36 countries, and European Community Respiratory Health Survey data in 18 countries. There were positive correlations between paracetamol sales and symptoms of wheeze, rhinoconjunctivitis and eczema. An increase in paracetamol sales of lOg/capita was associated with an increase of 5.2% in asthma symptoms in 13- to 14-year-olds and 2.6% in adults [90(111)1. [Pg.49]

Asthmatic attacks due to non-narcotic analgesics, mostly occur in patients with so-called intrinsic or idiosyncratic asthma (often associated with nasal polyposis, sinusitis and eosinophilia of the blood) (McFadden and Austen 1977). About 10% of patients with this kind of asthma show severe reactions to aspirin, methyl-salicylate, pyrazolone derivatives, indomethacin, ibuprofen, diclofenac and sometimes even phenacetin and paracetamol. (Sodium salicylate is often tolerated.) The special reactivity may appear only in later life and concerns a number of chemically unrelated drugs. In some of these patients analgesic therapy with a morphine derivative such as pentazocine (Fortalgesic) or hyoscine butylbromide (Buscopan) may be necessary. However, in other patients, those with aspirin urticaria rather than asthma, the reaction may also rely on a drug-specific allergic mechanism (de Weck 1971). [Pg.195]

Respiratory More evidence has been published on the topic of paracetamol use and asthma. In a prospective birth cohort study of 620 children with a first-degree family history of allergic disease, who were followed until age 7 years, the use of paracetamol was associated (with borderhne significance) with a risk of childhood asthma, but the association became clearly non-significant after adjustment for the frequency of respiratory infections [17 ]. There was no association between the use of paracetamol for non-respiratory causes and asthma. [Pg.184]

Lowe AJ, Carlin JB, Bennett CM, Hosking CS, Allen KJ, Robertson CF, Axelrad C, Abramson MJ, Hill DJ, Dharmage SC. Paracetamol use in early life and asthma prospective birth cohort study. BMJ 2010 341 c4616. [Pg.190]

Respiratory More evidence has been published about the possible association between paracetamol and asthma. In a multicenter case-control study of 521 patients with asthma and 507 controls, weekly use of paracetamol, compared with less frequent use, was associated with asthma [25 ]. A study of 19 349 adult twins ermoUed in the nationwide Danish Twin Registry showed a higher prevalence of asthma in subjects with frequent intake of paracetamol (OR = 2.16 95% C3 = 1.03, 4.53) after adjusting for confounders [26 "]. Furthermore, a study of 205 487 children aged 6-7 years showed that paracetamol use for fever in the first year of life was associated with a higher risk of asthma... [Pg.244]

Thomsen SF, Kyvik KO, Skadhauge L, Steffensen I, Backer V. Intake of paracetamol and risk of asthma in adults. J Asthma 2008 45(8) 675-6. [Pg.252]

Beasley R, Clayton T, Crane J, von Mutius E, Lai CK, Montefort S, Stewart A. ISAAC Phase Three Study Group. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years analysis from Phase... [Pg.252]

Many patients who respond to aspirin with asthma, rhinitis and urticaria are also sensitive to other analgesic anti-inflammatory drugs. Cross-sensitivity has been demonstrated with indomethacin, mefenamic acid, flufenamic acid, phenylbutazone, paracetamol, fenoprofen and ibuprofen (37, 39, 40C, 44C 4gc 55C 566 57R) Furthermore, cross-sensitivity may also occur with widely used food additives and colourings such as benzoic acid and the acidic yellow dye tartrazine (46 ", 47, 57, 58 ). In Holland tartrazine is used in the colouring of at least 79 pharmaceutical formulations including antibiotics and even preparations... [Pg.67]


See other pages where Asthma paracetamol is mentioned: [Pg.1120]    [Pg.1120]    [Pg.276]    [Pg.290]    [Pg.1004]    [Pg.716]    [Pg.724]    [Pg.202]    [Pg.828]    [Pg.480]    [Pg.387]    [Pg.245]    [Pg.252]    [Pg.1115]    [Pg.1122]   
See also in sourсe #XX -- [ Pg.30 , Pg.129 ]




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