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Prostaglandin pathway

In susceptibie individuais, NSAIDs may precipitate acute bronchospasm. It affects 10-20% of adults with asthma but is rare in asthmatic children. The mechanism is related to cyclooxygenase inhibition, with shunting of arachidonic acid metabolism from the prostaglandin pathway to the biosynthesis of ieukotrienes with increased mucosal permeability and bronchospasm. Susceptible patients should avoid NSAIDs since the bronchospasm may be severe and has been fatal. Paracetamol in doses up to 1000 mg daiiy wiii be toierated by most patients. True type I allergic reactions to NSAIDs, with specific IgE, are rare but anaphyloactoid reactions have occasionally been described in patients with a history of aiiergy or bronchiai asthma. [Pg.135]

What this allows is targeting of either the cyclooxygenase or leukotriene arms of the prostaglandin pathways. Although this is a convenient separation of mechanisms, there is often overlap. It is for this reason, for example, that postoperative cataract patients are administered both topical steroids and NSAIDs. [Pg.233]

The prostaglandin pathway Renal prostanoid receptors Cyclooxygenase isoforms 420 421 422... [Pg.419]

Moodley J, Norman R. Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. Prostaglandins Leukot Essent Fatty Acids 1989 37 145-147. [Pg.230]

The PG endoperoxide can be further processed by three metabolic routes (1) the primary prostaglandin pathway, (2) the prostacyclin pathway, and (3) the thromboxane pathway. The two major prostaglandins that are synthesized in the primary pathway are PGF2 and PGE2. The major prostacyclin is PGI2, and thromboxane A2 is the principal thromboxane formed. As mentioned earlier, all the prostaglandins turn over rapidly and their metabolic products can be found in urine and feces. [Pg.150]

Phytosterols are another important terpene subclass. Two sterol molecules that are synthesized by plants are p-sitosterol and its glycoside. In animals, these two molecules exhibit anti-inflammatory, antineoplastic, antipyretic, and immune-modulating activity [29]. Ph34osterols were reported to block inflammatory enzymes, for example, by modifying the prostaglandin pathways in a way that protected platelets [30]. [Pg.4603]

Cudaback E, Jorstad NL, Yang Y, Montine TJ, Keene CD. Therapeutic implications of the prostaglandin pathway in Alzheimer s disease. Biochem Pharmacol. 2014 88(4) 565-572. [Pg.108]


See other pages where Prostaglandin pathway is mentioned: [Pg.140]    [Pg.934]    [Pg.12]    [Pg.58]    [Pg.60]    [Pg.13]    [Pg.149]    [Pg.1453]    [Pg.1458]    [Pg.1464]    [Pg.485]    [Pg.146]    [Pg.420]    [Pg.429]    [Pg.121]    [Pg.144]    [Pg.280]    [Pg.289]    [Pg.177]    [Pg.241]    [Pg.95]    [Pg.648]    [Pg.32]   
See also in sourсe #XX -- [ Pg.31 ]




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