Pantoprazole pharmacological properties

Cheer SM, Prakash A, Faulds D, et al. Pantoprazole An update of its pharmacological properties and therapeutic use in the management of acid related disorders. Drugs 2003 63 101-132. 

Prilosec, Rapinex, Zegerid) and its S-isomer, esomeprazole (Nexium), lansoprazole (Prevacid), rabeprazole (Aciphex), and pantoprazole (Protonix). These drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties. Omeprazole is a racemic mixture of R- and S-isomers the S-isomer, esomeprazole (S-omeprazole), is eliminated less rapidly than R-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. Despite claims to the contrary, all proton-pump inhibitors have equivalent efficacy at comparable doses. 

HM (2003) Pantoprazole an update of its pharmacological properties and therapeutic use in the meuiagement of add-related disorders. Drugs 63 101-132. doi 10.2165/(XXX)3495-200363010-(XXX)6 (d) Riel MA, Kyle DE, Bhattachaijee AK, Milhous WK (2(X)2) Mechanisms of action physiological effects efficacy of proton pump inhibitor drugs ageiinst plasmodium falciparum in vitro and their probable. Pharmacophores Antimicrob Agents Chemother 46 2627-2632. doi 10.1128/AAC.46.8.2627-2632.2002 (2002) Chem Abstr 137 259873... 

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