Pantoprazole sodium sesquihydrate

The calculated water content of pantoprazole sodium sesquihydrate is 6.25%. 

In 1986, pantoprazole sodium sesquihydrate was synthesized and from 1987 onwards the development was switched to the sodium salt (BY 1023). This was more soluble and more stable, and had better compatibility with other excipients used in the drug formulation. Pantoprazole was identified after nearly seven years of research and registered for clinical use after a further seven years of development. Finally, it reached its first market in 1994 in Germany. During the course of the studies on pantoprazole, more than 650 PPIs had been synthesized and evaluated. 

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