Panaxadiol

Ginsenoside Rbj is a representative of the saponins derived from 20 (S )-proto-panaxadiol (Fig. 1). It exhibits central nervous system-depressant and antipsychotic... 

Gynostemma pentaphyllum (Thunb.) Makino Joe Koo Lan (root) Panaxatriol, panaxadiol, saponin, glypenosides, sterol.33-34349350351 Regulating effect on lymphocyte transformation, protective effect against myocardial and cerebral ischemia, relax isochemic heart ventricles. 

Panax notoginseng (Burk) F. H. Chen Tian Qi (root) Ginsenosides, panaxatriol, panaxadiol, dencichine, saponins flavonoids.53-425 A stimulant, tonic expectorant, anti-inflammatory. 

Panax zingiberensis C. Y. Wu . M. Feng San Qi (root) Saponins including arasaponins, panaxadiol, panaxatriol.33 This herb is mildly toxic. Arrest bleeding, remove blood stasis, relieve pain. Treat angina pectoris, hemorragic diseases. 

Fig. 2.47. 13C NMR spectra of anhydro-panaxadiol (15 tng/mL deuteriochloro-form 100.6 MHz (a-e) 400 scans (f) 1600 scans) (a) proton broadband decoupled (f) proton off-resonance decoupled (b) subspectrum of quaternary carbon atoms resulting from a /-modulated spin-echo experiment (c-e) edited CH(I subspectra obtained from DEPT experiments with 0f = 45c, 90° and 135° [57],...

FIGURE 37.1 Structures of ginsenoids based on chemical structure there are two major groups (A) panaxadiols and (B) panaxatriols. 

Li and co-workers demonstrated the use of SFC in the analysis of panaxadiol and panaxatriol in ginseng, a famous traditional Chinese medicine [28 J. A capillary SB-cyanopropyl-50 column with a carbon dioxide mobile phase and flame-ionization detector was used for the analysis. Methyltestosterone was used as an internal standard for the quantitation. Figure 7.17 shows the SFC separation. The method was found to be linear (r > 0.999) in the range studied and the precision obtained was in the range 2.2-5.7%. 

Figure 7.17 Capillary supercritical fluid chromatograms of ginseng extract. (1) Methyltestosterone (internal standard), (2) panaxadiol, (3) panaxatriol. [Reprinted from Ref. 28, Biomedical Chrom. (1992) with kind permission of John Wiley and Sons, Ltd., UK.]...

Shibata S, Fujita M, Itokawa H, Tanaka O. Studies on the constituents of Japanese and Chinese crude drugs. XL Panaxadiol, a sapogenin of Ginseng roots. Chem. Pharm. Bull. 1963 1 759. Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J. Korean Med. Sci. 2001 16(suppl S) S28-S37. 

Asian ginseng P. ginseng) contains a wide variety of flavonoids, saponins, steroids, sesquiterpenoids, and triterpenoids. These include ginsenolides and ginsenosides, pro-topanaxadiol, panaxadiol, panaxatriol, and panasinsene. 

Effect of panaxadiol saponin (PDS) on phorbol ester induced change of protein kinase C activity in cardiomyocytes of rats was investigated[19]. Partially purified protein kinase C was incubated with PDS at concentration of 1 to 1000 U g/ml for ten minutes in vitro. The activity of kinase C was inhibited in a dose-dependent manner by PDS. In cardiomyocytes preincubated with PDS at concentration of250, 500,1000 P g/ml, respectively, for ten minutes, PMA-induced decrease of cytosol protein kinase C activity and increase of membrane protein kinase C activity were greatly inhibited in the same manner. PDS not only inhibited protein kinase C in vitro, but also inhibited activation of protein kinase C in cardiomyocytes. 

II. Structure and Chemistry of Dammarane Sapogenins 1. Panaxadiol, an Artifact... 

Rbi, a representative of the saponins derived from 20(S)-proto-panaxadiol (26) (Table I) reportedly exhibited central nervous system-depressant and antipsychotic activity, protection of stress ulcer, increase of gastrointestinal motility and weak anti-inflammatory action, while Rgi, the major saponin of 20( S)-protopanaxatriol (36) (Table II) showed weak central nervous system-stimulant action, antifatigue action and aggravation of stress ulcer (757, 752, 755, 164, 165, 166). Kaku etal. 167) on investigating the pharmacology of the major saponins, reported the... 

Shibata, S., M. Fujita, H. Itokawa, O. Tanaka, and T. Ishii Studies on the Constituents of Japanese and Chinese Crude Drugs XL Panaxadiol, a Sapogenin of Ginseng Roots (1). Chem. Pharm. Bull. (Japan) 11, 759 (1963). 

Hiai, S., H. Oura, H. Hamanaka, and Y. Odaka A Color Reaction of Panaxadiol with Vanillin and Sulfuric Acid. Planta Medica 28, 131 (1975). 

Saruwatari, Y., H. Besso, K. Futamura, T. Fuwa, and O. Tanaka Thin Layer Chromatographic Determination of Panaxadiol and Panaxatriol by Ultraviolet Derivatization. Chem. Pharm. Bull. (Japan) 27, 147 (1979). 

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