Panaxadiol saponins

Gynostemma pentaphyllum (Thunb.) Makino Joe Koo Lan (root) Panaxatriol, panaxadiol, saponin, glypenosides, sterol.33-34349350351 Regulating effect on lymphocyte transformation, protective effect against myocardial and cerebral ischemia, relax isochemic heart ventricles. 

Effect of panaxadiol saponin (PDS) on phorbol ester induced change of protein kinase C activity in cardiomyocytes of rats was investigated[19]. Partially purified protein kinase C was incubated with PDS at concentration of 1 to 1000 U g/ml for ten minutes in vitro. The activity of kinase C was inhibited in a dose-dependent manner by PDS. In cardiomyocytes preincubated with PDS at concentration of250, 500,1000 P g/ml, respectively, for ten minutes, PMA-induced decrease of cytosol protein kinase C activity and increase of membrane protein kinase C activity were greatly inhibited in the same manner. PDS not only inhibited protein kinase C in vitro, but also inhibited activation of protein kinase C in cardiomyocytes. 

Ginsenoside Rbj is a representative of the saponins derived from 20 (S )-proto-panaxadiol (Fig. 1). It exhibits central nervous system-depressant and antipsychotic... 

Panax notoginseng (Burk) F. H. Chen Tian Qi (root) Ginsenosides, panaxatriol, panaxadiol, dencichine, saponins flavonoids.53-425 A stimulant, tonic expectorant, anti-inflammatory. 

Panax zingiberensis C. Y. Wu . M. Feng San Qi (root) Saponins including arasaponins, panaxadiol, panaxatriol.33 This herb is mildly toxic. Arrest bleeding, remove blood stasis, relieve pain. Treat angina pectoris, hemorragic diseases. 

Shibata S, Fujita M, Itokawa H, Tanaka O. Studies on the constituents of Japanese and Chinese crude drugs. XL Panaxadiol, a sapogenin of Ginseng roots. Chem. Pharm. Bull. 1963 1 759. Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J. Korean Med. Sci. 2001 16(suppl S) S28-S37. 

Asian ginseng P. ginseng) contains a wide variety of flavonoids, saponins, steroids, sesquiterpenoids, and triterpenoids. These include ginsenolides and ginsenosides, pro-topanaxadiol, panaxadiol, panaxatriol, and panasinsene. 

Rbi, a representative of the saponins derived from 20(S)-proto-panaxadiol (26) (Table I) reportedly exhibited central nervous system-depressant and antipsychotic activity, protection of stress ulcer, increase of gastrointestinal motility and weak anti-inflammatory action, while Rgi, the major saponin of 20( S)-protopanaxatriol (36) (Table II) showed weak central nervous system-stimulant action, antifatigue action and aggravation of stress ulcer (757, 752, 755, 164, 165, 166). Kaku etal. 167) on investigating the pharmacology of the major saponins, reported the... 

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